Progesterone – The Almost Forgotten Hormone

Progesta CareHistorically, estrogen and how it affects us has been the most commonly talked about sex hormone. However, the importance of progesterone, which is another type of sex hormone, is often overlooked. Progesterone imbalance affects both women and men.

Scientific research is beginning to shed light on the importance of maintaining a balance between progesterone and estrogen for overall health and well being. It is also beginning to show the significant differences between natural and synthetic progesterone.

The primary hormones that are prescribed for hormone replacement therapy (HRT) or birth control pills are derived from synthetic sources and do not have the same function in the body that our own biological hormones do.

Studies have shown that synthetic hormones are linked to an increase in certain types of cancer, strokes, and heart disease. According to the Women’s Health Initiative study, an experiment involving hormone replacement therapy was stopped early due to the increase in breast cancer. Breast cancer rates have dropped significantly since reports of this study were released in 2002.

Risks and Benefits of Estrogen Plus Progestin in Healthy Postmenopausal Women

Discussion on Routine Hormone Replacement Therapy (Journal of Epidemiology & Community Health)

Presently, natural progesterone (bio-identical hormone therapy) is beginning to get recognition for its beneficial effects.

According to Dr. John R. Lee, an authority on hormone balancing, “natural progesterone has a molecular structure identical to the progesterone produced by the human body and is created through the fermentation process of the Mexican wild yam.”

Lowered Progesterone Levels

For women, from the time menses begins until menopause, levels of estrogen and progesterone ebb and flow in a manner which promotes reproduction. At about age 35 to 40, women reach the time of premenopause, which is when their levels of progesterone and estrogen begin to reduce.

Normal Hormone Progression

Normal Hormone Progression

During this time through age 50, there is a 35% drop in estrogen, but a 75% reduction in progesterone occurring simultaneously. This is normal, and does create many pre-menopausal symptoms that we accept as part of the aging process.

Many premenopausal women in their mid to late thirties, as well as many women in the menopausal stage are overloaded with estrogen. At the same time they are suffering from progesterone deficiency because of the severe drop in physiological production during this period. There is then insufficient progesterone to counteract the amount of estrogen in our body. It is most noticeable among perimenopausal women who do not ovulate, which is quite common. You may have a fairly normal cycle, but no egg is released and very little progesterone is produced.

Importance of Progesterone

“Progesterone is an essential hormone that also plays a part in the development of healthy nerve cells and brain and thyroid function. Synthetic progestins tend to block the body’s ability to produce and utilize natural progesterone to maintain these life promoting functions.” ~

Progesterone can help prevent estrogen from becoming harmful to our health among other protective factors. Therefore, supplementing with a natural progesterone cream, such as Progesta-Care or Progesta-Care for Men, can help correct hormonal imbalances that cause symptoms associated with estrogen dominance.

Progesterone is also the primary hormone of fertility and pregnancy. It is essential to the survival of the fertilized egg, the embryo, and the fetus. In pregnancy, it prevents the shedding of the uterine lining, as a drop in progesterone can result in a miscarriage.

Natural progesterone helps to counterbalance the negative effects of estrogen. When there is not enough progesterone to counterbalance estrogen, one may begin to have symptoms of estrogen dominance. Common symptoms include PMS, heavy or irregular periods, irritability, weight gain, anxiety, hair loss, low libido, fibrocystic breasts, endometriosis, and uterine fibroids, to name a few. Men can also experience symptoms related to to estrogen dominance.

Symptoms of Progesterone Deficiency in Women and Men

Symptoms in WomenSymptoms in Men
  • Hot Flashes
  • Breast Tenderness
  • Fibrocystic Breasts
  • Anxiety
  • Hair Loss
  • Bone Loss
  • Low Libido
  • Night Sweats
  • Irregular Periods
  • Vaginal Dryness
  • Depression
  • Insomnia
  • Infertility
  • Weight Gain
  • Acne
  • Bloating
  • Mood Swings
  • Memory Lapses
  • Loss of Muscle
  • Nervousness
  • Excess Facial/Body Hair
  • Heavy or Painful Periods
  • Urinary Incontinence
  • Poor Concentration
  • Irritability
  • Prostate problems
  • Breast enlargement
  • Bone/Muscle Loss
  • Impotency
  • Atherosclerosis
  • Male patterned baldness
  • Weight gain
  • Low libido

Causes of Imbalance Between Progesterone and Estrogen

  • Stress
  • Obesity
  • Poor Liver Function
  • Birth Control Pills
  • Plant Estrogens (soy, flaxseed, red clover)
  • Hormone Replacement Therapy
  • Peri-menopause
  • Glandular Dysfunction
  • Environmental estrogens

Progesterone as a Building Block

Furthermore, progesterone is a building block for many other hormones, including the corticosteroids, which are produced by the adrenal glands and are essential for stress response, electrolyte balance, blood pressure, and lastly, survival. Without adequate progesterone, synthesis of the cortisones is impaired and the body turns to alternate pathways. These alternate pathways have masculine-producing side effects, such as long facial hairs and thinning of scalp hair. Cortisol, DHEA, testosterone, and estrogen are all made from progesterone in a process that begins with cholesterol.

Dr. Lee Hormone Balance Made SimpleImportance of Balancing Progesterone and Estrogen

Hormones have a profound effect on your everyday health and well-being. Although only present in tiny amounts, they effect on every cell. Not only do hormones have individual effects, but they also interact with each other to produce dramatic effects in the body. Because of these interactions, they are able to trigger multiple body systems.

The balance of progesterone and estrogen in a woman’s body is very important. At different times in the life of a woman, hormonal imbalance can be caused by stress, obesity, poor liver function, birth control pills, plant estrogens (soy, flaxseed, red clover), hormone replacement therapy, peri-menopause, glandular dysfunction, and environmental estrogens.

Regardless of the cause, the end result of an imbalance between estrogen in relation to progesterone adds up to a condition Dr. John Lee has termed “estrogen dominance”, as mentioned above. This condition can result in symptoms of PMS, perimenopause, or menopause.

Dr. Lee’s book Hormone Balance Made Simple explains this and more, in-depth.

Natural (bio-identical) Progesterone Cream

A natural, bio-identical progesterone cream or spray may be beneficial for you. We offer these products and more at Energetic Nutrition. As always, check with your doctor before you begin any hormone supplementation program.

progesta care creamProgesta-Care for Women

Natural progesterone cream helps maintain a normal level of progesterone. It also helps supplement low progesterone levels assisting in proper hormone balance between estrogen and progesterone. Since natural progesterone has been shown to be biologically identical to the same hormone women produce it offers an alternative to taking synthetic hormones. It can be safely used by menstruating women, premenopausal to peri-menopausal women, and those who are menopausal.

progesta care mens formulaProgesta-Care for Men

Men, too can suffer from estrogen dominance. Estrogens from environmental and food sources (xenoestrogens) can produce hormonal stimuli that can contribute to inappropriate growth of mammary tissue cells, resulting in a problem society is now calling “man boobs”. Read more on our Men’s Progesterone page.

Progesta-Care PlusProgesta-Care PLUS

Progesta-Care PLUS is for women feeling they need phytoestrogens in addition to progesterone. Some find the combination of both estrogen and progesterone to be helpful in managing hormone fluctuations.


Benefits of Natural Progesterone Include

  • Promotion of  a healthy sex hormone balance
  • Having a calming effect
  • Help to enhance mood
  • Help to normalize menstrual cycles
  • Increase sex drive
  • Help use fat for energy

Problems with Synthetic Progesterone (Progestin)

It is important to understand the difference between natural bio-identical progesterone and synthetic progesterone commonly known as progestin. Natural progesterone is not a patentable product. Therefore, the pharmaceutical companies have altered this hormone to produce synthetic progestins, which are patentable and are generally used in contraceptives and hormone replacement therapy (HRT). Synthetic progestins are not exact replicas of the body’s natural progesterone. Even though there is a big difference between the effects of natural and synthetic progesterone, doctors often interchange their names.

“The synthetic version of this hormone is not really progesterone; it is a progestin. Progestins are synthetic progesterone-like compounds manufactured by pharmaceutical companies. Synthetic progesterones are far more powerful than the body’s own natural progesterone and are metabolized as foreign substances into toxic metabolites. Synthetic progesterone (progestin) can gravely interfere with the body’s own natural progesterone, create other hormone-related health problems, and further exacerbate estrogen dominance.” ~ Ward Dean, MD

Unfortunately, there is a long list of side effects, some of which are quite severe.

Side Effects of Synthetic Progesterone (Progestin)
  • headaches
  • depression
  • fluid retention
  • increased risk of birth defects
  • increased risk of miscarriage
  • liver dysfunction
  • breast tenderness
  • breakthrough bleeding
  • acne
  • insomnia
  • hirsutism (hair growth)
  • edema
  • weight changes
  • pulmonary embolism
  • pre menstrual (like) syndrome

Most importantly, synthetic progestins lack the intrinsic physiological benefits of progesterone, thus they cannot function in the major biosynthetic pathways as progesterone does and they can disrupt many fundamental processes in the body.

More Posts on Hormones

Achieve Healthy Estrogen Balance with Myomin

Could Estrogen Dominance Be Responsible for Your Weight Gain, Decreased Libido, Fatigue?

The Skinny on Fat – And the Role Hormones and Obesogens Play

Related Products

DIM Pro Energetic Nutrition DIM is an excellent hormone balancer, particularly in an estrogen dominant body.DIM™ is a naturally occurring phytonutrient that is found in cruciferous vegetables. Though discovered many years ago, the connection between plant-derived dietary ingredients and estrogen metabolism are just now beginning to be understood.
Clary Sage Essential OilClary Sage Essential Oil may benefit women and men at various ages and stages in life.* It may support a healthy attitude during PMS*, boost libido and feelings of sexual desire*, and improve mood, and reduce cramps and water retention associated with the menstrual cycle*.
ease femin menopausal supportEaseFemin™ is the first all natural dietary supplement containing Isoƒactor™ a premium extract from exotic Brazilian Red Propolis that helps women reduce the difficult symptoms that often accompany menopause including hot flashes*, night sweats*, and irritability*.
Myomin Natural Hormone BalancerMyomin has been shown to help metabolize unhealthy estrogens and promote proper hormonal balance in the body.* Clinical case studies show that Myomin is able to reduce estradiol (estrogen) levels in as little as 10 days.
n-fuzed Estro-FemN-fuzed Estro-Fem increases progesterone and helps balance estrogen. It is an effective means to assist women through their menopausal years by reducing or eliminating many symptoms associated with normal hormone fluctuations in aging women.
n-fuzed TestosteroneN-fuzed Testosterone is the perfect, all natural alternative to messy creams and injections. It may quickly stimulate the body’s natural processes to increase testosterone levels.*
Patchouli Essential OilPatchouli Essential Oil may regulate libido and stimulate healthy hormone balance in both men and women. *

Further Reading




  1. Dania sidan says

    What if the progesteron level is high ? What are the side effect?
    I am takink aldacton as treatment for aldosteron high level and high blood pressure and recently i have done a blood test that shows my progesteron level is high about 5,1? Pls i need your help.

  2. Vanessa says

    I’m interested to know if you are aware what happens when a person comes off Myomin. I’ve been taking it for over a year- I think it has been helpful although I’ve been taking other things too. I now want to TTC and think I should stop. Have you any experience of this?

    Many thanks- Vanessa

  3. says

    I never realized that progesterone was such an important hormone in men and women. The list of benefits sounds like it could help me with my irregular menstrual cycles. I wonder if I could benefit from a progesterone crème.

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Content on this blog is for reference purposes and is not intended to substitute for advice given by a physician, pharmacist, or other licensed health-care professional. You should not use this information as self-diagnosis or for treating a health problem or disease. Contact your health-care provider immediately if you suspect that you have a medical problem.

* These statements have not been evaluated by the U.S. Food and Drug Administration (FDA) or This product is not intended to diagnose, treat, cure or prevent any disease.