Ketsumeisei
Wang’s Special Blend to Help Maintain
Normalized Blood Sugar

What is Ketsumeisei?

Ketsumeisei is a proprietary herbal compound that includes sickle-pod senna, cape jasmine fruit, astragalus root, Chinese wild yam, kudzu vine root, safflower, Chinese licorice, and Chinese ginseng. Ketsumeisei has been formulated to improve metabolic and microcirculatory disturbances like those associated with Type II diabetes mellitus and insulin resistance. 

Ketsumeisei is indicated for the maintenance of normalized blood sugar levels and insulin resistance disorders, such as:

• Obesity
• Hyperlipidemia
• Hyperinsulinemia
• Hypertension
• Arteriosclerosis
• Arteriosclerotic diseases

Studies have shown that glucose levels can be decreased or maintained with less insulin or oral hypoglycemic agents when using 6 grams per day of Ketsumeisei. The suggested use is 3 grams per day.

Composition of Ketsumeisei

Improvement of the constitution (physical functions of the body) is based on the notion of traditional Chinese medicine.  This method uses a collective effect of natural ingredients to improve an abnormal constitution instead of focusing on a single symptom or a single parameter.  According to this philosophy, people with type 2 diabetes have a constitution of liver and blood stagnation, a qi (vital force) deficiency, as well as internal inflammation. 

These types of constitutions can cause disorders of energy production and circulation, which should be improved by the principle of soothing the liver, clearing away heat, tonifying qi, and activating the blood.  A text book of traditional Chinese medicine describes the indications for Chinese herbal ingredients. 

Soothing the liver – means ensuring smooth flow in the liver.  Chinese herbal ingredients for soothing the liver have the effect of protecting hepatocytes, improving circulation in the liver, and promoting bile secretion. 

Clearing away heat – means suppressing inflammation.  Chinese herbal ingredients for clearing away heat have immunostimulating, detoxifying, and anti-inflammatory effects. 

Tonifying Qi (chi) – means restoring impaired functions.  Malaise and delayed healing of tissue damage are typical symptoms of a qi deficiency.  A qi deficiency corresponds to low energy conditions.  The comprehensive function of digestion, absorption, and metabolism is called spleen qi.  Chinese herbal ingredients for tonifying qi have the effect of improving digestive, absorptive, and metabolic functions; promoting the healing of damaged tissue; and enhancing immunity.

Activating blood – means resolving stagnant blood, indidcating improvement in circulatory disorders.  Chinese herbal ingredients for activating blood have the effect of improving microcirculation as well as anti-fibrotic, anti-thrombotic, and anti-tumor effects. 

According to the above principles, edible herbal ingredients were used to devise the supplement Ketsumeisei to help improve one’s constitution. 

Who Can Benefit From Ketsumeisei?

Ketsumeisei is appropriate for people with insulin resistance syndrome or microcirculation failures. This includes diabetes, angina, myocardial infarction, eyestrain, anapeiratic red-eye, glaucoma, cataract, constipation, angitis, and phlebeurysm, after effects of stroke, vascular dementia, side effects of anticancer agents, postoperative recovery, intestinal adhesion, congestion resulting from injury, menstrual irregularities, stiff shoulder, coptosis, and anemia.

Ketsumeisei is for people with:

• Pre-diabetes
• Hypoglycemia (low blood sugar)
• Type II diabetes
• Poor metabolism
• Circulatory problems
• High blood pressure

Note: A common constitution underlies type 2 diabetes.  Therefore, constitutional improvement and lifestyle modification can help facilitate recovery.  Furthermore, prevention and early intervention before the development of significant symptoms may substantially reduce medical costs and improve the quality of life.

Read more at the American Institute of Eastern Medicine website.

Ketsumeisei and Diabetes

Increase in Type II diabetes mellitus:

Diabetes mellitus has become increasingly prevalent, so much so that it is, in fact, currently referred to as a “national affliction.”  Type II diabetes, which accounts for about 95% of diabetes mellitus, results from insufficient insulin secretion and insulin resistance (in which insulin cannot be used effectively).  Genetic factors are involved in its etiology, but stress, overeating, lack of exercise, and other modern lifestyle habits also play a large role.  These predisposing factors promote the formation of the “diabetic constitution,” which is characterized by metabolic and circulatory disorders.

Dangerous complications of Type II diabetes mellitus:

Type II diabetes is most insidious for its complications.  It is not uncommon for complications to continue to progress even though the blood sugar is well-controlled.  Diabetes mellitus ranks first among diseases for complications.  Current for the complications are not adequately effective, and the need to use multiple medications often leads to adverse reactions.  Treatment of diabetes mellitus must not focus solely on lowering the blood sugar, but must also incorporate measures to improve the constitution. 

High blood sugar is just one of the many symptoms of diabetes mellitus.  A continued state of metabolic and circulatory disorder may lead to such pathologies and retinopathy, nephropathy, neuropathy and myocardial infarction (MI), and continue to induce pathological changes throughout the body. (moved down here

Ketsumeisei as prevention and treatment of Type II diabetes mellitus:

Ketsumeisei is good for the prevention and treatment of Type II diabetes, its complications and insulin resistant syndromes.  Ketsumeisei’s systemic effects improve metabolism and microcirculation disturbances in the body.  Free fatty acid in the body is insulin resistant material.  In clinical studies, Ketsumeisei clearly decreases free fatty acid in Type II diabetics.  This product also helps decrease glucose indirectly by correcting insulin resistance as a result of the decrease of free fatty acid.  Microcirculation disturbance can cause multiple complications.  The proprietary mix of ingredients (including flavonoid & diadzein in fruit kudzuvine, carthamidin in safflower, and saponin in Korean ginseng) can help improve total body microcirculation.

Subjective symptoms in diabetics:

Diabetics also suffer from various other symptoms including malaise and numbness.  Chinese wild yam and licorice are reported to be anti-fatigue and excitometabolic.  Most diabetics recognize improvement in various subjective symptoms in a few weeks and improved activity levels have been noted.  Additionally, cape jasmine and licorice have been shown to have ant-inflammatory effects.  Symptoms of retinopathy or acro-tetraplegia (paralysis), if present, improved within a month of using Ketsumeisei.  Shortness of breath by stenocardia (angina pectoris) was also improved. 

Liver Function and diabetes:

After a meal, non-diabetics store approximately 40% of glucose in the liver before being distributed to the blood as required.  People become diabetic if there is insulin resistance caused by functional decline or disease of the liver.  All Type II diabetics suffer from minor functional diseases of the liver, such as fatty liver, and slow flow of blood and bile.  When these minor functional diseases of the liver are treated, metabolism accelerates.  Ketsumeisei’s ingredients including flatstem milkvetch root, cape jasmine and licorice can help improve liver function.   When these minor functional diseases of the liver are treated, metabolism accelerates.  Ketsumeisei’s ingredients, including cape jasmine and licorice can help improve liver function.

Results

Treatments for diabetics has always included lowering and controlling the patient’s blood sugar levels, yet this approach often fails to stop further complications and may cause serious side effects, especially, when the patient is taking several drugs. Ketsumeisei offers a way to improve symptoms to help prevent more damage.

In one study, 60% of diabetics taking Ketsumeisei experienced decreased glucose within 2 months.  Nearly 100% of diabetics experienced improvement of subjective symptoms during the same time period.  For example, observations of patients with type 2 diabetes showed that oral doses of Ketsumeisei in combination with hypoglycemic agents for 1 to 2 months resulted in improvements of malaise and other symptoms, while substantially decreasing blood levels of free fatty acids.  There was also a trend toward reduction in fasting and postprandial (after meals) blood glucose levels.1,2

Clinical studies have shown that in Type II diabetic patients, Ketsumeisei can clearly:

• Help improve metabolism
• Help lower blood pressure
• Help increase ATP (energy of the cells)
• Help decrease or maintain glucose levels
• Help decrease free fatty acid, which may contribute to insulin resistance

Please Note:  Direct or indirect measurements of blood glucose levels are now used as criteria for evaluation of the outcome of treatment for type 2 diabetes.  However, just changing blood glucose levels does not always reflect other symptoms associated with this disease.  For example, some patients have no improvement in the symptoms of malaise and numbness despite a reduction in blood glucose levels.  And, some patients treated with therapy to improve their constitution recover sufficiently to resume work without obvious reductions in blood glucose levels.  In other words, symptomatic improvement is not always accompanied by improvement in laboratory data. 

In one study, 60% of diabetics taking Ketsumeisei experienced decreased glucose within 2 months. Nearly 100% of diabetics experienced improvement of subjective symptoms during the same time period.

Studies and Research

Ketsumeisei (Juemingjing) and Type II Diabetes
Juemingjing extract is formulated to maintain normalized blood sugar levels and keep a healthy circulatory system.

Ketsumeisei (Juemingjing) and Diabetes
Effects on diabetes, including changes of serum free fatty acid and TNF-a.

Traditional Chinese Medicine Theory

The “spleen” of traditional Chinese medicine refers to the functional system that controls digestion, absorption, and metabolism. The diabetic constitution is attributed to the metabolic and circulatory pathologic condition associated with “spleen vacuity”, stagnant blood, and liver-kidney yin deficiency. The primary pathology is “spleen vacuity”, characterized by metabolic disorder. This leads to microcirculatory disorder (stagnant blood), which leads to inadequate synthesis of bodily substances (e.g., blood-pressure-controlling substances as liver-kidney yin). Type II diabetes is not rapid onset. The diabetic constitution commonly predates the abnormal rise in blood sugar. Onset of diabetes and diabetic complications may be prevented by early correction of the constitution.

Ketsumeisei is recommended by the Embassy of the People’s Republic of China in Japan and the Japan-China Society, Inc.

Ingredients Defined

Sickle-Pod Senna
Helps lower blood pressure and blood sugar, improving liver disorders and inflammation.  Treatment for eye disease by clearing away liver inflammation.

Chinese Wild Yam
Helps nourish and strengthen the body, improving physical strength, while helping to promote energy metabolism.

Safflower
Helps improve blood flow by activating stagnant blood and help reduce inflammation.

Astragalus Root
Helps invigorate the immune system, suppress ulcers, and promote energy metabolism.  It can also help prevent oxidation, protect against radiation injury, promotes wound healing, protects the liver, and lower blood pressure. 

Cape Jasmine Fruit
May help alleviate fever and inflammation, while helping to aid liver functions.

Kudzu Vine Root
Helps relieve wasting thirst, lower blood pressure, reduce glucose, and inhibits platelet aggregation.

Chinese Licorice
Helps alleviate inflammation, cough,  and allergy symptoms.  It can help suppress peptic ulcer and diabetes, while helping to protect the liver, improve liver function, and prevent liver cell damage.  It may also aid urination and work like steroid hormones.  

Chinese Ginseng
Helps decrease fatigue and the level of cortisol in the blood.  It can also act as an anti-inflammatory, promote metabolism, dissolve blood clots, stimulate mental activity, relieve pain and swelling, while detoxifing and normalizing the entire system. 

Dr. Xianen Wang, MD, PhD

Dr. Xianen Wang began investigating viable diabetes treatments when he noticed that the
disease was on the rise, with increasing numbers of patients suffering and dying from complications. The development of insulin and medications did not lower the incidence.
Because genetic and molecular therapies provide only local treatment for certain symptoms, Dr. Wang formulated Ketsumeisei, a proprietary herbal compound that has been widely used in China and Japan to treat diabetes for many years.

Dr. Wang’s ongoing involvement in diabetes is practical and solution-oriented, emphasizing
studies that will directly alleviate patients’ pain, rather than studies for purely academic purposes. Dr. Wang was granted an Associate Professorship at China’s Tongji Medical College in 1995, and became a Full Professor there in 2002. In December 2005, he became an Associate Professor in the Department of Gastroenterology, as well as a Japan’s very first Foreign Associate Professor at Juntendo University’s School of Medicine, http://www.juntendo.ac.jp/english/index.html.

Meet Dr. Wang:
http://www.americaninstituteoeasternmedicine.com/about_wang.html

More information about Dr. Wang’s work is available online at:
www.americaninstituteofeasternmedicine.com

Further Reading:
 
Ketsumeisei FAQs 

Supplement Facts
Serving Size: One (1) Packet
Formulation:  Ketsumeisei is packaged in granular form in 3,000 mg doses per packet.
Servings per Container: 30 Packets, 90 g
Amount per Serving: 3,000 mg

Proprietary blend contains: Sicklepod Senna, Chinese Wild Yam, Safflower, Astragalus Root, Cape Jasmine Fruit, Kudzu Vine Root, Chinese Licorice, Chinese Ginseng.

Contains no artificial colors, flavors, or preservatives. No wheat, gluten, soy or talc.

Suggested Use: As a dietary supplement, per day without food, or as recommended by your healthcare professional:

Adults and children over 12 years: 3,000 mg (1 packet) per day
Children 6 to 12 years: 1,500 mg (1/2 a packet) per day
Children under 6 years: 1,500 mg (1/2 a packet) per day

For severe symptoms, recommended dosage for adults and children over 12 years is 6,000 mg (2 packets) per day for 4 to 8 weeks.

Tear open package contents and empty into your mouth and follow with a glass of water. Take immediately after opening.

WARNING: If you are pregnant or lactating, consult a healthcare professional before using. Ketsumeisei improves blood circulation, so the intake of blood thinners may need to be reduced or stopped under a doctors supervision. Ketsumeisei cannot be taken by patients with a history of hypersensitivity to any of its components. Keep out of reach of children. Consult your physician if an allergic reaction occurs. Do not use this product if the safety seal is broken. Store in a cool dry place.

Country of Origin: People’s Republic of China

Imported by: American Institute of Eastern Medicine

Ketsumeisei Wang’s Special Blend to Help Maintain Normalized Blood Sugar from World Nutrition 30 Packets – 3,000 mg. $149.00 Quantity 1 2 3 4 5 6 7 8 9 10 Add to cart

References

1.  Wang XE, et al. Therapeutic effect of the Kampo formula Ketsumeisei on diabetes mellitus.
Eastern Medicine. 2002;18(3):43-49

2.  Wang XE.  Effect of Ketsumeisei on diabetes mellitus and changes in blood free fatty acids and TNF-a. Eastern Medicine. 2007;23:17-22.