Magnesium Malate is a compound of magnesium and malic acid, clinically shown to soothe and energize muscle cells. Malic acid is a natural fruit acid that is present in most cells in the body and is an important component of numerous enzymes key to ATP synthesis and energy production. Therefore, magnesium malate may be helpful in those suffering from fatigue due to fibromyalgia.
Magnesium is an essential mineral in over 300 enzymatic reactions in metabolism. These reactions include those involved in the Krebs cycle (one of the body's main energy production processes), energy storage, the breakdown of fatty acids, protein synthesis, DNA metabolism, neurotransmitter activity, and hormone regulation. Magnesium is stored primarily in the bones and plays a role in the absorption of calcium by the bones.
Magnesium Malate: Metabolic Energy and Metal Cleansing
Magnesium Malate is a highly absorbable form of magnesium that provides the benefits of this mineral, along with the benefits of malic acid, a nutrient found to contribute to the process of transforming food into ATP, the body's energy source. Malic acid is a metabolite in the Krebs cycle, as mentioned above, which is responsible for the biochemical reactions that produce 90 percent of the energy in the cells of the body.
This compound is most highly esteemed for helping to:
- Produce energy
- Soothe muscles
- Eliminate aluminum
Malic acid is known to cross the blood-brain barrier and bind to aluminum, helping to draw this metal away from a particular enzyme so magnesium can plug into the receptor sites instead, supporting nerve cell growth and communication. The harmful aluminum can now be flushed out of the brain and the body.
The cause of fibromyalgia is not fully understood. However, some leading fibromyalgia researchers believe that there is a malfunction in the body's ability to manufacture energy. The muscles burn energy faster than it can be produced, which is compounded by a shortage of the nutrients necessary to make the energy. This may cause the muscles to rely too heavily on the inefficient (anaerobic) energy cycle for much of their energy production instead of the more efficient (aerobic) energy cycle. Malic acid plays a key role in the production of energy in the cells; therefore, it is often recommended with magnesium for fibromyalgia and chronic fatigue syndrome.
Some fibromyalgia patients may be magnesium deficient. An article in the Journal of Nutritional Medicine pointed out that many fibromyalgia patients have responded quite favorably to magnesium malate. Magnesium and malic acid are important substances in the manufacture of energy for the human muscle cell.
Malic Acid and Fibromyalgia
Recent studies have indicated that those with fibromyalgia tend to have decreased levels of magnesium in comparison
to the control groups. According to a study published in the Journal
of Nutritional Medicine, Abraham et al hypothesized
that a magnesium deficiency found in muscles cells
could possibly play a role in the development of fibromyalgia.
The group demonstrated that a daily supplement of
300-600 of malate acid resulted in improvements
of symptoms, as well as in the number and severity
of tender points.
Magnesium is an essential mineral in over 300 enzymatic
reactions in metabolism. These reactions include those
involved in the Krebs cycle (one of the body's energy
production systems), such as:
- DNA metabolism
- Vital for cell formation
- Activation of B vitamins
- Energy transport and storage
- The breakdown of fatty acids
- Proper nerve function and neurotransmitter
- The formation and maintenance of protein,
fatty acids, and bone.
- The formation of adenosine triphosphate
(ATP), the body's energy source.
Magnesium Malate is a highly absorbable form of magnesium
that provides the benefits of this mineral, along
with the benefits of malic acid, a nutrient found
to contribute to the process of transforming food
into ATP, the body's energy source. Many fibromyalgia
sufferers have stated that the combination of magnesium
and malic acid have been helpful for their symptoms
associated with fibromyalgia.
Studies on Magnesium and Malic Acid to Reduce Fibromyalgia Pain
In a 1992 study 15 fibromyalgia patients received an oral dose of 1200-2400 mg of malate (malic acid) and 300-600 mg of magnesium over a four and 8 week period. Patients reported a reduction in pain across a tender point index (TPI). Six subjects felt an improvement in 48 hours.
During another study conducted in 1995, researchers gave 24 subjects with fibromyalgia a low tablet with 50 mg magnesium and 200 mg malic acid. Scientists measured pain levels through patient self-assessment and the tender point index. Results showed that the low dose, short term trial was not effective to reduce fibromyalgia pain. However, higher doses over an extended duration significantly reduced subjects' pain.
Clinical Trial: Magnesium
Malate and Fibromyalgia
There are many people with fibromyalgia that have
reported positive benefits from taking magnesium in
combination with malic acid, as well as studies to
back them up. For example:
In a randomized, placebo-controlled, open-label,
crossover trial (grade I evidence-based), Abraham
et al used a combination of magnesium (300-600 mg)
and malate (1,200-2,400 mg) in 15 patients during
an eight-week period. The results showed a statistically significant
clinical improvement (P < 0.001) in the treatment
group vs. placebo as measured by two outcomes. TPI
scores (± SE) of 19.6 ± 2.1 prior
to treatment decreased to 8 ± 1.1 and 6.5
± 0.74 at four and eight weeks, respectively,
on the mag-malate combination. Conversely, following
an average of eight weeks, six patients were switched
to placebo for two weeks. Their TPI scores increased
significantly (P < 0.001) from 6.8 ± 0.75
to 21.5 ± 1.4. Subjective improvement of
fibromyalgia symptoms occurred within 48 hours of
magnesium supplementation in the mag-malate group;
symptoms worsened in the placebo group.
Many practitioners have found it to be useful in
a pain reduction regimen for this disease at a higher
dosage (up to 600 mg magnesium and 2,400 mg malic
Other Potential Uses
Blood levels of Magnesium have been lower in females with PMS and since it can help relax muscle tissues and may be involved in neurotransmitters responsible for improved moods, women with PMS may find it helpful.
Chronic Fatigue Syndrome
Levels may be low in CFS sufferers. Magnesium that is bound to an organic compound called malic acid is absorbed from the body in higher amounts and may have an effect in reducing the pain of CFS.
It has been observed that most diabetics have low levels of this mineral. Magnesium supplementation can also improve insulin production in elderly people with type 2 diabetes.
Headaches – Migraines
Magnesium is an essential mineral and is needed for muscle relaxation; therefore, it has been shown to be very useful in all types of headaches, especially the types that may be hormonally related.
Muscle Relaxation and Stress
Magnesium has been shown to help with muscle relaxation, heart health, and normal stress responses. Magnesium also works with vitamin B6 in several enzymatic pathways in the body, so it can be beneficial to take them together.
Mitani, K. 1992 “Relationship between...aluminum load...and magnesium status.”Magnesium Research 5(3):203-13
Yoshida, S. 1991 “Environmental factors in western Pacific foci...role of Aluminum(Al)...” Rinsho Shinkeigaku 31(12):1310-2
Costello, RB.; Moser-Veillon, PB. 1992 “A review of magnesium intake...” Magnesium Research 5(1):61-7
Yasui, M; Yase, Y; Ota, K; Garruto, RM. 1991 “Aluminum deposition... from the Kii Peninsula of Japan.”
GE, Glechas ID. "Management of fibromyalgia: A rationale for the use of magnesium and malic acid." Journal of Nutritional Medicine,1992;3:49-59.
Russell IJ, et al. "Treatment of fibromyalgia syndrome with Super Malic: A randomized, double blind, placebo controlled, crossover pilot study." Journal of Rheumatology, 1995; 22:953-958.
"The Team Value of Magnesium and Malic Acid," Marc D. Braunstein, Oralchelation.com. Accessed 11/6/08.
Capsules per Container: 200 Capsules, 625 mg
Serving Size: Six (6) Capsules
Servings per Container: 33
Suggested Use: 6 capsules daily
Supplement Facts for 625 mg Capsule
Serving Size: 6 capsule(s)
|Magnesium (as magnesium malate)
|Malic acid (as magnesium malate and malic acid)
* Percent Daily Values (%DV) are based on a 2,000 calorie diet.
† Daily Value not established.
Other Ingredients: gelatin (capsule), microcrystalline cellulose, magnesium stearate, and silica.
Hypoallergenic: Contains no yeast, dairy, egg, gluten, corn, soy, or wheat. Contains no sugar, starch, salt, preservatives, artificial colors, flavor, or fragrance.
Warning: If you are pregnant, may become pregnant, or breastfeeding, consult your health care professional before using this product. Do not use if either tamper-evident seal is broken or missing. Keep out of the reach of children.
Manufactured by Source Naturals