DIM - The Estrogen Metabolizer

DIM™ is a naturally occurring phytonutrient that is found in cruciferous vegetables. Though discovered over ten years ago, the connection between plant-derived dietary ingredients and estrogen metabolism are just now beginning to be understood. Research has shown that DIM has the ability to act as an estrogen balancer in both women and men. It can be used by those addressing estrogen dominance problems and seeking to reduce conditions such as uterine fibroid tumors, fibrocystic breasts, and other women's fibrosis related conditions.

DIM in its pure crystalline form requires an absorption enhanced delivery system for use in dietary supplements. Therefore, Energetic Nutrition has chosen to use Dr. Michael Zeligs’ BioResponse DIM under the name DIMPRO with a patented absorption enhanced formula in order to bring you the highest quality product we could find.

Dr. Zeligs not only suggests DIM for balancing women’s hormones, he also recommends DIM for the symptoms of hormonal imbalance in men, such as weight gain, hair loss, and prostate enlargement. A balance of hormones can help bring the health advantages all of us would like to achieve:

The dietary use of micronutrients found in plants, which are also known as phytochemicals, encompasses what we now know as Phytonutrition. The phytochemical DIM (diindolylmethane) that naturally occurs in broccoli, cauliflower, cabbage, and Brussels sprouts has been shown to increase the regulation of hormone metabolism. The plant indoles in these cruciferous vegetables promote health and scientists have discovered that adding these plants to the diets of animals could prevent certain forms of cancer. DIM is more biologically active than other indoles found in the cruciferous vegetable family.

Supplementing with Dim can help overcome the need to eat 3 pounds of broccoli per day and can effectively shift the balance of sex hormones. “An optimal estrogen balance has implications for cancer prevention and successful aging in both women and men,” according to Dr. Michael Zeligs, M.D., co-author of the “All About DIM” book.

DIM can help increase the specific aerobic metabolism for estrogen, multiplying the chance for estrogen to be broken down into its beneficial or "good" estrogen metabolites. Many of the benefits that are attributed to estrogen, which includes its ability to protect the heart and brain with its antioxidant activity, are now known to come from these "good" metabolites.

A slow metabolism of estrogen can result in too much active estrogen known as estradiol in the body; this can be problematic for both sexes. In women, elevated estradiol levels have been shown to cause weight gain (waist, thighs, hips), moodiness, and breast pain. Men tend to suffer from weight gain, loss of sex drive, prostate enlargement, and male patterned baldness, to name a few.

When supplemental DIM increases the ‘good’ estrogen metabolites that are known to be antioxidants, there is a simultaneous reduction in the levels of undesirable or ‘bad’ estrogen metabolites which are not antioxidants and can actually cause cancer.

Taking DIM not only promotes healthy estrogen metabolism, it can also promote a more desirable action from testosterone. “Testosterone supports energy and mood and helps sustain interest in sex for both men and women”, according to Dr. Zeligs.

Many women in their twenties, mid thirties through forties, and even women who are menopausal can be overloaded with estrogen. At the same time they may be suffering from a deficiency of progesterone due to a severe drop in the body’s production, which leads to insufficient progesterone to counteract the amount of estrogen in the body. It is most noticeable among peri-menopausal women who do not ovulate, which is quite common. You may have a fairly normal cycle, but no egg is released and very little progesterone is produced.

Even if a woman has low estrogen levels, she can have symptoms of estrogen dominance, because she may have little or no progesterone. However, estrogen dominance can be caused by more than the body’s production of hormones. For example

Men can benefit from taking DIM, as they too can suffer from estrogen dominance. Estrogens from plants and environmental sources, also known as xenoestrogens, produce hormonal stimuli that can contribute to inappropriate growth of mammary tissue cells, resulting in a problem society is calling “man boobs.” Some theorize that estrogen dominance in men is also contributing to:

Therefore, both women and men who are suffering from estrogen dominance can benefit from taking an estrogen metabolizer such as DIM that can help bring hormones back into balance.

DIM has a unique ability to affect estrogen metabolism, as mentioned above. Normally, estrogen metabolizes along one of two very distinct pathways, one pathway leads to tumor growth, and the second leads to tumor suppression. One physician hypothesizes that this second pathway may prevent estrogen from entering certain cellular receptor sites causing tumor growth.

As DIM works to regulate hormones by increasing the body’s production of healthy estrogen by decreasing the undesirable forms, cells are protected and tumor growth is inhibited. It is important to remember that there are different forms of the three main estrogens that are important to women and they are estradiol, estrone, and estriol.

Research involving DIM has identified two good estrogens, 2-hydroxy estradiol and 2-hydroxy estrone. These are the antioxidants of the estrogen world and induce the self-destruction of tumor cells. When these two estrogens are low, tumor growth is more likely to occur. DIM increases the body’s production of these healthy estrogens.

Supplementing with DIM helps reduce the estrogen metabolites now known to be responsible for the cancer initiating and cancer promoting effects of estrogen by lowering the two bad forms, 16-hydroxy estrone and 4-hydroxy estrone, which are linked to tumor growth. These so called “bad” estrogens can have a negative impact by allowing oxidation of cells, damage of DNA, and the promotion of cancer. It can be said that DIM interferes with cells that are prone to divide and grow in the presence of these two particular forms of estrogen.

In short, DIM increases the good estrogens, and decreases the bad estrogens. Research suggests DIM may reduce the risk of breast, uterine, cervical, and prostate cancers. These cancers are estrogen related and that is why it is so important to reduce estrogen dominance in both women and men. The following chart demonstrates how estrogen is metabolized into its beneficial forms:

For women, estrogen is a good thing when metabolized correctly. It improves mood, memory, assists with overall function, and lowers the risk of breast and uterine cancer, all of which are associated with estrogen dominance, as mentioned above. Furthermore, properly metabolized estrogen can also produce beneficial effects from testosterone which helps support moods, as well as libido and energy.

In menstruating women, estrogen may not be metabolized due to many different factors, such as stress, diet, poor liver function, obesity, xenoestrogens from environmental chemicals, and pesticide residues in food. DIM’s conversion of unhealthy estrogen metabolites into the beneficial forms will not only help protect against hormone related cancers, it can also help with the symptoms associated with hormonal imbalance, including PMS, as suggested by Dr. Zeligs.

In premenopausal women, the first age-related hormonal imbalance involves a decreased production of progesterone. This reduction in progesterone output during the second half of the menstrual cycle, can cause irregular periods and contribute to premenstrual mood disorders. The “good estrogen” metabolites stimulate increased progesterone production from ovarian cells. Hormonal imbalances in premenopausal women can also be attributed to the same factors as menstruating women listed above.

Another cause of hormone imbalance in menstruating and premenopausal women is birth control pills. Taking DIM can have a balancing effect benefiting disorders and symptoms associated with estrogen-progesterone imbalance, including but not limited to:

In Menopausal women with prolonged exposure to Hormone Replacement Therapy (HRT), DIM can help decrease estrogen-related breast cancer and other estrogen related disorders.

It was once believed that women who are menopausal/postmenopausal have low levels of estrogen. However, this may no longer be the case. While it may be true that women in this phase of life are no longer producing as much estrogen as they did in prior years, many are still remaining estrogen dominant due to the long term use of hormone replacement therapies, exposure to environmental estrogens, obesity, poor liver function, and declining progesterone production.

DIM supplementation is an effective means to insure positive estrogen metabolism, especially for those who are or have used long term HRT, as it can provide a margin of safety while reducing the negative consequences of “bad” estrogen metabolites.

DIM is generally recommended for those who are menstruating (early thirties), premenopausal (mid-thirties on) with high estrogen levels. Menopausal women using HRT, as mentioned above can also use DIM to help counter balance the negative effects associated with this type of hormone therapy.

Menopausal women who are not using HRT can use Myomin which is a Chinese herbal formula that can help reduce excess estrogen, as well. This product is not as strong of a metabolizer as DIM and is often suggested for those who are menopausal to post-menopausal because they are not producing as much natural estrogen.

Myomin and DIM can also be used safely by women in their twenties and thirties. Because DIM has actions that differ from Myomin, many women who are not menopausal choose to take them both for a more aggressive approach.

Dim is not only beneficial in reducing symptoms of estrogen dominance in women such as, fibroid tumors, fibrocystic breasts, endometriosis, breast pain, moodiness, and loss of sex drive, it can also benefit men by improving estrogen-dominance related health issues such as hair loss, atherosclerosis, prostate problems, lowered libido, man boobs, and impotency.

German Researchers have documented a correlation between age related accumulations of estrogen in human prostate glands with the presence of benign prostate enlargement.

This research suggests the role of estrogen as a growth promoting hormone in men, as well as women. Dr. Zeligs states, “the accumulation of this particular hormone is indicative of male ‘andropause’. Increased PSA (prostate specific antigen) production was shown to be specifically inhibited by 2-methoxyestradiol, the beneficial form of estrogen metabolites, which is promoted by DIM.” Therefore, supplementing with DIM is the ideal way for men to get rid of unwanted estrogen, as too much estrogen not only leads to prostate problems, it can also lessen the action of testosterone.

DIM works by promoting more “free” testosterone that can help maximize the body’s response to weight training and dramatically changes the fat-burning ability of men. When a man is estrogen dominant, the body produces a protein that testosterone can bind to, and then it is no longer considered to be in its “free” beneficial form; bound testosterone can have undesirable effects similar to that of excess estrogen. For example, low libido, excess weight gain, impotence, and depression.

Scientific studies have shown that high levels of “free” testosterone and low levels of estrogen have been linked to lean body mass, an efficient fat-burning metabolism, and low abdominal obesity. Other benefits from “free” testosterone are improved moods, cardiovascular health, memory, libido, and better overall physical conditioning.

According to Zeligs, “testosterone exerts its actions differently depending on whether it is free or bound to carrier proteins in the blood.” When estrogen is metabolized into the good hydroxyl forms, as mentioned above it has the ability to set testosterone free by bumping it off of the testosterone binding proteins.

DIM supplementation can help promote fat loss by reducing the levels of unhealthy estrogens that can cause excess weight to be deposited around the abdomen, thighs, and hips in both women and men. Naturally, DIM can be even more effective when combined with a low-fat, high-fiber diet, as well as exercise.

Furthermore when studied, the combination of “good” estrogen metabolites in conjunction with an increase in “free” testosterone promoted by DIM, is responsible for a more active release of fat cells that have been stored in the body by increasing metabolism.

"Improving estrogen metabolism with DIM results in direct and indirect support for more efficient weight training. Using DIM can help provide the first estrogen-management system for women and men. ‘Good’ estrogen metabolites directly support muscle well-being through their antioxidant action,” says Dr. Zeligs.

DIM can be used during intense workouts with maximum weights to develop larger and stronger muscles quickly. Dr. Zeligs also states, “You can start out with this as your goal, then move to lighter weight and more reps to encourage complete growth of new muscles. This regimen will maximize your metabolic rate and keep you fit and trim.”

Many health care professionals are now beginning to recognize a link betwen hormone imbalances and fibromyalgia symptoms. Like hormone imbalances, fibromyalgia can be one of the most frustrating and elusive problems that conventinal medicine is facing today. Most physicians would like to help their patients, but they generally do not know what to do beyond prescribing medications that are aimed at reducing symptoms, instead of addressing the underlying cause(s). DIM has been shown to help reduce excess estrogen levels that lead to symptoms that are associated with estrogen domiance and fibromyalgia. For example:

In its pure, crystalline state, diindolylmethane (dim) is inadequately absorbed by the human body. To be beneficial, pure DIM Diindolylmethane needs to be made bioavailable. This hurdle was cleared in 1998 when BioResponse Nutrients developed its unique and patented delivery system - the only method known to produce truly absorbable DIM. BioResponse DIM is the first and only patented, absorption-enhanced formulation of diindolylmethane. For this reason, Energetic Nutrition uses the formulation of DIM available only from BioResponse. We have named it DIMPRO.

DIM helps reduce the levels of undesirable or ‘bad’ estrogen metabolites. One of the processes by which estrogenic compounds and toxins are metabolized, broken down, and eliminated is through the conjugation and glucuronidation processes that occurs in the liver. However, there is an enzyme known as Beta-Glucuronidase that can interfere with the elimination process by breaking the bond between the used hormone/toxin and the water soluble substance that was designed to carry them out of the body.

Fortunately, Calcium D-Glucarate can help to inhibit or stop the beta-glucuronidase enzyme that can interfere with this process, allowing the body to properly eliminate them. Calcium D-Glucarate is an important part of fully eliminating excess estrogens and toxins. We highly recommend Calcium D-Glucarate for anyone's dietary supplement program, and particularly when taking DIM.

BioResponse DIM is the only DIM that is being used in all clinical trials, including clinical trials to study HPV, cervical dysplasia, uterine, and prostate health.

Clinical trials are currently underway using BioResponse DIM in collaboration with Cornell University, the NYU School of Medicine, Cancer Research UK, Wayne State University, and New York Medical College in HPV related conditions and prostate health.

Additionally, BioResponse Nutrients works with the National Cancer Institute (NCI) under a clinical trials agreement to discover the further health potential of DIM. BioResponse is the only DIM manufacturer that supports clinical trials with such organizations.

Scientists discovered that broccoli was able to prevent certain types of cancer when given to study animals over twenty years ago. Recent scientific studies have shown when animals were given supplemental DIM in place of broccoli, the same cancer protection resulted.

DIM’s estrogen balancing and anti-tumor properties, especially for prevention, have been well-documented. A 1999 study on human breast tumor cells found that DIM blocked estrogen receptor tumor cells. This is due to the fact that DIM and estrogen are not only similar in structure; they also share similar metabolic pathways.

Researchers concluded that DIM possessed anti-estrogenic properties and in effect frees testosterone. All this, teamed with the apparent fat-burning activity of DIM, leads experts to conclude that DIM is safe, effective, and has many potential uses.

National Cancer Institute - The National Cancer Institute (NCI) coordinates the Nation’s research program on cancer prevention, detection, diagnosis, treatment, rehabilitation, and control. BioResponse Nutrients works with the NCI to discover the further health potential of DIM.

ClinicalTrials.gov - ClinicalTrials.gov is a service of the U.S. National Institutes of Health and lists clinical trials conducted in the United States and around the world. Visit this site to see Active Clinical Studies using BioResponse DIM (BR-DIM).

DIM FAQ - An online resource site about Diindolylmethane (DIM). Includes references, published articles and abstracts on DIM, and more.

Hormonal Balance - for more information about balancing hormones when you have fibroid tumors.

Estrogen Dominance - For further information about hormones, estrogen dominance, and environmental estrogens.

Calcium D-Glucarate - is an important supplement in fully eliminating excess estrogens and toxins.

Natural Progesterone and Myomin - for other products which may also assist with obtaining hormonal balance.

DIM FAQ - An online resource site about Diindolylmethane (DIM). Includes references, published articles and abstracts on DIM, and more.

DIMPRO also contains phosphatidylcholine. Phosphatidylcholine's role in the maintenance of cell-membrane integrity is vital to all of the body's basic biological processes. Clinical studies have demonstrated that choline is essential for normal liver function. When the liver is functioning properly, it is able to efficiently metabolize estrogen. Phosphatidylcholine is derived from soy, in a form that does NOT include any phytoestrogens, so it is safe for those who are estrogen dominant.

DIM may alter the clearance of the following: Coumadin (warfarin), caffeine, theophylline, dilantin, tegretal, or other anti-seizure medications. Use of DIM should be avoided by individuals taking the above listed medications. DIM can be used in conjunction with phytoestrogens for those in need of estrogen balancing. Anyone taking prescriptions medications should consult with a doctor or pharmacist prior to taking DIM.

Women who are on oral contraceptives as a means of birth control are advised to use an alternative method of contraception, as DIM may reduce the pill's contraceptive effectiveness.

DIM supplementation has not been studied on pregnant or nursing women and should be avoided unless recommended by a health care professional.

Nausea and/or headahces can be seen in some individuals taking DIM, improving at a reduced, lower dose. Care should be taken in individuals with a history of migraine headaches.

Servings per Container: 120 Capsules, 75mg

Amount per Serving: Proprietary blend 75mg including:

Suggested Use: As a dietary supplement, take 1 to 4 capsules per day (75 to 300 mg), or as directed by your healthcare professional. We suggest 2 to 4 per day for most women with fibroid tumors. The further from menopause you are, generally the higher the dose you can take. Most customers not experiencing menopausal symptoms take 4 per day. Men can take up to 6 capsules (400 mg) per day. Please do check with your health care practitioner to determine the proper dosage for you.

Caution: Not for use if pregnant, planning to get pregnant, lactating, or using birth control pills. If taking prescription medications, consult your health care professional. Harmless color changes in urine may occur - drinking extra water will help reduce this.

Enhanced Absorption: The absorption of our DIMPRO is superior to regular diindolylmethane and its unstable precursor, indole-3-carbinol (l3C) due to the patented complex from BioResponse. BioResponse DIM insures that you will get a stabilized dose and consistent benefit from each capsule.

Manufactured for Energetic Nutrition, Inc. Licensed from BioResponse, LLC. DIMPRO™ is a trademark of BioResponse, LLC. BioResponse DIM is a patented enhanced bioavailability complex that makes this phytonutrient absorbable, which makes it easier for the body to utilize.

References:

1. Dalessandri KM, Firestone GL, Fitch MD, Bradlow HL, Bjeldanes LF. Pilot study: effect of 3,3'-diindolylmethane supplements on urinary hormone metabolites in postmenopausal women with a history of early-stage breast cancer. Nutr Cancer.2004;50(2):161-7.

2. Bradlow HL, Telang NT, Sepkovic DW, Osborne MP. 2-hydrodyestone: the 'good' estrogen. J Endocrinol. 1996. Sep;150 Suppl:S259-65.

3. Zeligs, MA, Brownston PK, Sharp ME, Westerling KC, Wilson SM, Jons SM.Managing cyclical mastalgia with Absorbable Diindolylmethane: A randomized, Placebo-controlled Trial. JANA. 2005; 8(1):5-15.

4. Zeligs MA, Fulfs JC, Peterson R, Wilson SM, McIntyre L, Sepkovic DW, and Bradlow HL. In vivo, uterine-protective activity of absorption-enhanced diindolylmethane: Animal and preliminary human use in combination with Tamoxifen. Proc Am Assoc Cancer Res 2003.44:1268.

5. Zeligs MA, Sepkovic DW, Manrique C, Macsalka M, Williams DE, and Bradlow HL. Absorption-enhanced 3,3'-Diindolylmethane: Human Use in HPV-related, Benign and Precancerous Conditions. Proc. Am. Assoc. Cancer Res. 2002 Apr; 43, 3198.

6. Teas J, Cunningham JE, Fowke JH, Nitcheva D, Kanwat CP, Boulware RJ, Sepkovic DW, Hurley TG, Herbert JR. Unrinary estrogen metabolites, prostate specific antigen, and body mass index among African-American men in South Carolina. Cancer Detect Prev. 2005; 29(6):494-500.

7. Visit: http://clinicaltrials.gov, keyword:"diindolylmethane."

Chang YC Rilby J, Chang GH, Peng BC, Firestone G, Bjeldanes LL. Cytostatic and antiestrogenic effects of 2-(indol-3-ylmethyl)-3,3'-dinndolymethane, a major in vivo product of dietary indole-3-carbinol. Biochem Pharmacol, 1999 Sep 1;58(5):825-34.

DIMPRO Estrogen Metabolism Support for Women and Men

DIMPRO
Estrogen Metabolism Support
for Women and Men