Magnesium Malate is a compound of magnesium and malic acid, clinically shown to soothe and energize muscle cells. Malic acid is a natural fruit acid that is present in most cells in the body and is an important component of numerous enzymes key to ATP synthesis and energy production. Therefore, magnesium malate may be helpful in those suffering from fatigue due to fibromyalgia.
Magnesium is an essential mineral in over 300 enzymatic reactions in metabolism. These reactions include those involved in the Krebs cycle (one of the body's main energy production processes), energy storage, the breakdown of fatty acids, protein synthesis, DNA metabolism, neurotransmitter activity, and hormone regulation. Magnesium is stored primarily in the bones and plays a role in the absorption of calcium by the bones.
Magnesium Malate is a highly absorbable form of magnesium that provides the benefits of this mineral, along with the benefits of malic acid, a nutrient found to contribute to the process of transforming food into ATP, the body's energy source. Malic acid is a metabolite in the Krebs cycle, as mentioned above, which is responsible for the biochemical reactions that produce 90 percent of the energy in the cells of the body.
This compound is most highly esteemed for helping to:
Malic acid is known to cross the blood-brain barrier and bind to aluminum, helping to draw this metal away from a particular enzyme so magnesium can plug into the receptor sites instead, supporting nerve cell growth and communication. The harmful aluminum can now be flushed out of the brain and the body.
The cause of fibromyalgia is not fully understood. However, some leading fibromyalgia researchers believe that there is a malfunction in the body's ability to manufacture energy. The muscles burn energy faster than it can be produced, which is compounded by a shortage of the nutrients necessary to make the energy. This may cause the muscles to rely too heavily on the inefficient (anaerobic) energy cycle for much of their energy production instead of the more efficient (aerobic) energy cycle. Malic acid plays a key role in the production of energy in the cells; therefore, it is often recommended with magnesium for fibromyalgia and chronic fatigue syndrome.
Some fibromyalgia patients may be magnesium deficient. An article in the Journal of Nutritional Medicine pointed out that many fibromyalgia patients have responded quite favorably to magnesium malate. Magnesium and malic acid are important substances in the manufacture of energy for the human muscle cell.
Recent studies have indicated that those with fibromyalgia tend to have decreased levels of magnesium in comparison to the control groups. [ 1 ] According to a study published in the Journal of Nutritional Medicine, Abraham et al hypothesized that a magnesium deficiency found in muscles cells could possibly play a role in the development of fibromyalgia. The group demonstrated that a daily supplement of 300-600 of malate acid resulted in improvements of symptoms, as well as in the number and severity of tender points.
Magnesium is an essential mineral in over 300 enzymatic reactions in metabolism. These reactions include those involved in the Krebs cycle (one of the body's energy production systems), such as:
Magnesium Malate is a highly absorbable form of magnesium that provides the benefits of this mineral, along with the benefits of malic acid, a nutrient found to contribute to the process of transforming food into ATP, the body's energy source. Many fibromyalgia sufferers have stated that the combination of magnesium and malic acid have been helpful for their symptoms associated with fibromyalgia.
In a 1992 study 15 fibromyalgia patients received an oral dose of 1200-2400 mg of malate (malic acid) and 300-600 mg of magnesium over a four and 8 week period. Patients reported a reduction in pain across a tender point index (TPI). Six subjects felt an improvement in 48 hours.
During another study conducted in 1995, researchers gave 24 subjects with fibromyalgia a low tablet with 50 mg magnesium and 200 mg malic acid. Scientists measured pain levels through patient self-assessment and the tender point index. Results showed that the low dose, short term trial was not effective to reduce fibromyalgia pain. However, higher doses over an extended duration significantly reduced subjects' pain.
There are many people with fibromyalgia that have reported positive benefits from taking magnesium in combination with malic acid, as well as studies to back them up. For example:
In a randomized, placebo-controlled, open-label, crossover trial (grade I evidence-based), Abraham et al used a combination of magnesium (300-600 mg) and malate (1,200-2,400 mg) in 15 patients during an eight-week period. [ 3 ] The results showed a statistically significant clinical improvement (P < 0.001) in the treatment group vs. placebo as measured by two outcomes. TPI scores (± SE) of 19.6 ± 2.1 prior to treatment decreased to 8 ± 1.1 and 6.5 ± 0.74 at four and eight weeks, respectively, on the mag-malate combination. Conversely, following an average of eight weeks, six patients were switched to placebo for two weeks. Their TPI scores increased significantly (P < 0.001) from 6.8 ± 0.75 to 21.5 ± 1.4. Subjective improvement of fibromyalgia symptoms occurred within 48 hours of magnesium supplementation in the mag-malate group; symptoms worsened in the placebo group.
Many practitioners have found it to be useful in a pain reduction regimen for this disease at a higher dosage (up to 600 mg magnesium and 2,400 mg malic acid).
Mitani, K. 1992 “Relationship between...aluminum load...and magnesium status.”Magnesium Research 5(3):203-13
Yoshida, S. 1991 “Environmental factors in western Pacific foci...role of Aluminum(Al)...” Rinsho Shinkeigaku 31(12):1310-2
Costello, RB.; Moser-Veillon, PB. 1992 “A review of magnesium intake...” Magnesium Research 5(1):61-7
Yasui, M; Yase, Y; Ota, K; Garruto, RM. 1991 “Aluminum deposition... from the Kii Peninsula of Japan.”
GE, Glechas ID. "Management of fibromyalgia: A rationale for the use of magnesium and malic acid." Journal of Nutritional Medicine,1992;3:49-59.
Russell IJ, et al. "Treatment of fibromyalgia syndrome with Super Malic: A randomized, double blind, placebo controlled, crossover pilot study." Journal of Rheumatology, 1995; 22:953-958.
"The Team Value of Magnesium and Malic Acid," Marc D. Braunstein, Oralchelation.com. Accessed 11/6/08.
Capsules per Container: 200 Capsules, 625 mg
Serving Size: Six (6) Capsules
Servings per Container: 33
Suggested Use: 6 capsules daily
Supplement Facts for 625 mg CapsuleServing Size: 6 capsule(s)
* Percent Daily Values (%DV) are based on a 2,000 calorie diet.
† Daily Value not established.
Other Ingredients: gelatin (capsule), microcrystalline cellulose, magnesium stearate, and silica.
Hypoallergenic: Contains no yeast, dairy, egg, gluten, corn, soy, or wheat. Contains no sugar, starch, salt, preservatives, artificial colors, flavor, or fragrance.
Warning: If you are pregnant, may become pregnant, or breastfeeding, consult your health care professional before using this product. Do not use if either tamper-evident seal is broken or missing. Keep out of the reach of children.
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