Vitalzym Supplement Facts Capsules per Container: 90, 270, or 450 Capsules Serving Size: Three (3) Capsules Amount per Serving: Proprietary Enzyme blend - 1500 mg. (500 mg per capsule)

Proprietary blend contains: Protease, serrapeptase, papain, bromelain, amylase, lipase, rutin and amla. For a full description of these ingredients, see below.

Other ingredients: Cellulose, maltodextrin, silicon dioxide, magnesium stearate, riboflavin, and chlorophyllin.

Vitalzym is natural. It contains no animal derivatives, artificial flavors, artificial colors, yeast or gluten. Vitalzym is also lactose free and contains no harmful talc. The serrapeptase is prepared in such a way that it dissolves in your intestines, not in your stomach, and it operates in an extremely wide pH range, allowing for better absorption.

WARNING: DO NOT take this product without the consent of your physician if you are currently taking anti-coagulants (blood thinners).

Manufactured by World Nutrition, Inc.

VitalzymX Supplement Facts Capsules per Container: 240 Serving Size: Three (3) Capsules Amount per Serving: Proprietary Enzyme blend - 304.5 mg.

Proprietary blend contains: Bromelain, Papain, Rutin, Amylase, Protease, Lipase, Serrapeptase, Amla extract, Lactobacillus sporogenes.

Other ingredients: Riboflavin, Medium-chain Triglyceride (MCT), Beeswax, Glycerin Fatty Acid Ester, Citric Acid, Soy Lecithin, Gelatin, Glycerin, Hydroxypropyl Methylcellulose Phthalate (HPMCP)

Note: The ingredients may not necessarily be in the order of activity levels, but will be in the order of mass quantity.  For example: Serrapeptase is #7 on the list because it is not the highest MASS amount, yet the activity level of this enzyme is as high as allowed in the United States. Please note: Activity levels and mass quantity levels are two different things.

Vitalzym X is natural. It contains no animal derivatives, artificial flavors, artificial colors, yeast or gluten. Vitalzym X is also lactose free and contains no harmful talc.

WARNING: DO NOT take this product without the consent of your physician if you are currently taking anti-coagulants (blood thinners). Discontinue two weeks prior to surgery. Keep out of children’s reach and direct sunlight. Store in a cool, dry place.

Manufactured by World Nutrition, Inc.

Proteolytic enzyme (Protease)

The term "proteolytic" refers to all enzymes that digest protein. Other classes of enzymes include Amylase a digestive enzyme that breaks down carbohydrates and Lipase a digestive enzyme that breaks down fat during the digestive process. Each of these help in the digestion of food which in turn helps with absorption of those essential nutrients in the diet. In the body, proteolytic digestive enzymes are produced in the pancreas, but supplemental forms of enzymes may come from fungal or bacterial sources, extraction from the pancreas of livestock animals (trypsin/chymotrypsin) or extraction from plants (such as papain from the papaya and Bromelain from pineapples). The primary uses of proteolytic enzymes in dietary supplements are used as digestive enzymes, anti-inflammatory agents and pain relievers.

There are a number of clinical trials showing the benefit of using oral proteolytic enzymes as a digestive aid. Proteolytic enzymes are also theorized to help reduce symptoms of food allergies and as a treatment for rheumatoid arthritis and other autoimmune diseases

Perhaps the strongest evidence for benefits of proteolytic enzyme supplements come from numerous European studies showing various enzyme blends to be effective in accelerating recovery from exercise and injury in sportsmen as well as tissue repair in patients following surgery. In one study of footballers suffering from ankle injuries, proteolytic enzyme supplements accelerated healing and got players back on the field about 50% faster than athletes assigned to receive a placebo tablet(1). A handful of other small trials in athletes have shown enzymes can help reduce inflammation, speed healing of bruises and other tissue injuries (including fractures) and reduce overall recovery time when compared to athletes taking a placebo(2-8). In patients recovering from facial and various reconstructive surgeries, treatment with proteolytic enzymes significantly reduced swelling, bruising and stiffness compared to placebo groups (9-11).

Serrapeptase

Serrapeptase, also known as Serratia peptidase, is a proteolytic enzyme isolated from the non-pathogenic enterobacteria Serratia E15. The enzyme is found naturally in the intestine of the silkworm, which is used by the silkworm to dissolve the cocoon and emerge as a moth. The enzymes are then extracted from the medium so that not a trace of fungus is left on the enzyme and the purity is assured.

Serrapeptase has many clinical uses including:

• as an anti-inflammatory agent (particularly for post traumatic swelling)
• for Fibrocystic breast disease and fibroid tumors
• for Bronchitis (Serrapeptase loosens and expels mucous)
• anti-edemic (prevents swelling and fluid retention)
• digests dead tissue, blood clots, cysts, and arterial plaque

The late German physician, Dr. Hans Nieper, used serrapeptase to treat arterial blockage in his coronary patients. Clinical studies show that serrapeptase induces fibrinolytic, anti-inflammatory and anti-edemic (prevents swelling and fluid retention) activity in a number of tissues, and that its anti-inflammatory effects are superior to other proteolytic enzymes(12).

Serrapeptase's most profound benefits, in addition to reducing inflammation, is reduction of pain, due to its ability to block the release of pain-inducing amines from inflamed tissues(13). Physicians throughout Europe and Asia have recognized the anti-inflammatory and pain-blocking benefits of this naturally occurring substance and are using it in treatment as an alternative to salicylates, ibuprofen, and other NSAIDs(14).

Both Bromelain and Papain are plant derived proteolytic enzymes. Bromelain, also known as bromelin, is a protein-digesting enzyme extracted from the flesh and stem of the pineapple plant, Ananas comosus. Papain, is a proteolytic enzyme isolated from the papaya plant, Carica papaya. Bromelain is most notable for its effectiveness in the reduction of inflammation and decreasing swelling, but the scope of its benefits continues to increase. As a natural anti-inflammatory enzyme, bromelain has many uses. Arthritis patients may reduce the swelling that causes joint pain by taking bromelain. Bromelain may also be helpful for the pain, numbness, tingling, aching, and loss of motor and sensory function in the fingers resulting from carpal tunnel syndrome (CTS) (15,16). Prevention of the adhesiveness of platelets to endothelial cell walls was accomplished with 0.1 mcg/ml of Bromelain(16a). Thus the benefit of bromelain occurs over a broad range of doses, and even small amounts may be beneficial to anyone at risk to thrombotic heart attack or stroke. Papain has been shown to be effective in preventing burn wound infection and helping remove dead cells(17). Papain is also used for the following:

• Defibrinating wounds in hospitals
• Preventing cornea scar deformation
• Used in treatments of jellyfish and insect stings
• To treat edemas, inflammatory processes, and in the acceleration of wound healing
• In low doses as an indigestion medicine

Papain has been used to treat ulcers, dissolve membranes in diphtheria and reduce swelling, fever and adhesions after surgery.

Also known as Indian gooseberry (Emblica officinalis) is the richest source of Vitamin C. It also contains tannic acid, glucose, protein, cellulose and Calcium. Amla is useful for stomach problems, it is antipyretic, hair tonic and nerve brain tonic. It's also useful in anemia, hyperacidity and in gynecological problems and epistaxis. Amla is considered to have restorative and preventive properties.

Is one of the many existing Flavonoids. Flavonoids are a class of water-soluble plant pigments. Flavonoids support health by strengthening capillaries and other connective tissue, and some function as anti-inflammatory, antihistaminic, and antiviral agents. Rutin and several other flavonoids may also protect blood vessels. Rutin was shown to stimulate wound healing in rats and augment the tensile strength of scar tissue significantly(18).

References

1. Buck JE, Phillips N. Trial of Chymoral in professional footballers. Br J Clin Pract.1970 Sep;24(9):375-7.

2. Craig RP. The quantitative evaluation of the use of oral proteolytic enzymes in the treatment of sprained ankles. Injury. 1975 May;6(4):313-6.

3. Fisher JD, Weeks RL, Curry WM, Hrinda ME, Rosen LL. Effects of an oral enzyme preparation, Chymoral, upon serum proteins associated with injury (acute phase reactants) in man. J Med. 1974;5(5):258-73.

4. France LH. Treatment of injuries with orally administered Varidase as compared to Chymoral and Tanderil. Praxis. 1968 May 14;57(19):683-5.

5. Gal P, Tecl F, Skotakova J, Mach V. Systemic enzyme therapy in the treatment of supracondylar fractures of the humerus in children. Rozhl Chir. 1998 Dec;77(12):574-6.

6. Hingorani K. Oral enzyme therapy in severe back pain. Br J Clin Pract. 1968 May 5;22(5):209-10.

7. Rathgeber WF. The use of proteolytic enzymes (chymoral) in sporting injuries. S Afr Med J. 1971 Feb 13;45(7):181-3.

8. Schwinger O. Results of oral enzyme therapy in wounds of muscles, tendons and bones after accidents. Wien Med Wochenschr. 1970 Sep 5;120(36):603-5.

9. Duskova M, Wald M. Orally administered proteases in aesthetic surgery. Aesthetic Plast Surg. 1999 Jan-Feb;23(1):41-4.

10. Hoernecke R, Doenicke A. Perioperative enzyme therapy. A significant supplement to postoperative pain therapy? Anaesthesist. 1993 Dec;42(12):856-61.

11. Lie KK, Larsen RD, Posch JL. Therapeutic value of oral proteolytic enzymes following hand surgery. Arch Surg. 1969 Jan;98(1):103-4.

12. Mazzone A, Catalani M, Costanzo M, Drusian A, Mandoli A, Russo S, Guarini E, Vesperini G. Evaluation of Serratia peptidase in acute or chronic inflammation of otorhinolaryngology pathology: a multicentre, double-blind, randomized trial versus placebo. J Int Med Res. 1990; 18(5):379-88.

13. Mazzone A, et al. Evaluation of Serratia peptidase in acute or chronic inflammation of otorhinolaryngology pathology: a multicentre, double blind, randomized trial versus placebo. J Int Med Res. 1990; 18(5):379-88.

14. Aso T et al. Breast engorgement and its treatment: Clinical effects of Danzen an anti-inflammatory enzyme preparation. The world of Obstetrics and Gynecology (Japanese). 1981; 33:371-9.

15. Petry, Judy J. "Nutritional supplements and surgical patients." AORN Journal (June 1997).

16. Kelly, G.S. "Bromelain: A Literature Review and Discussion of Its Therapeutic Applications." Alternative Medicine Review (November 1, 1996).

16a. Metzig, C et al Bromelain Proteases reduce human platelet aggregation in vitro, adhesion to bovine endothelial cells and thrombus formation in rat vessels in vivo. In Vivo 13 (1): 7-12 Jan-Feb 1999.

17. Starley, I. F.; Mohammed, P.; Schneider, G.; Bickler, S. W. The treatment of paediatric burns using topical papaya. Burns 1999 nov 25 (7) 636-9

18. Wilhelmi, G. Effect of O-(beta-hydroxyethyl)-rutiside on wound healing in the rat. J pharmacology 1979 19(2):82-85.

WARNING:If you are pregnant, lactating, a hemophiliac, taking anti-coagulants (such as Coumadin, Heparin and Plavix), blood thinners, or have a history of thinning blood in your family, do not take Vitalzym, VitalzymSEB, or NattoQ10 without direction and supervision from your medical provider. Discontinue use 2 weeks prior to surgery.