Other ingredients: Medium-chain triglycerides, starch, glycerin, polysaccharrides, corn protein*, beeswax, glycerin fatty acid ester, soy lecithin**, citric acid.
*The corn protein, which derived from non-GMO corn, is part of the enteric coating around the capsule, and comprises less than 1% of the total product. There has not been a single report of an allergic reaction due to the corn protein in Vitalzym, but we suggest that if you have concerns about allergies please contact your healthcare provider regarding your own personal sensitivity levels prior to taking this product. Corn protein was chosen over commonly-used phthalates (a dangerous plasticizer) for the enteric coating of the Vitalzym capsules.
**The soy lecithin acts an emulsifier, and is only in trace amounts - less than 1% of the entire product. Testing of soy lecithin has confirmed that no phytoestrogens are delivered to the body, and therefore there is no impact on hormones. People with a soy allergy have never reported any issues with Vitalzym capsules.
Vitalzym is natural and 100% vegetarian. It contains no artificial flavors, artificial colors, yeast or gluten. Vitalzym is also lactose free and contains no harmful talc.
Suggested Use: As a dietary supplement, take 3 capsules daily, or as recommended by your healthcare professional. Take capsules at least 30 minutes before a meal, 60 minutes after a meal, or any time in-between meals. Or, take an activation dose as recommended by a healthcare professional. Read Vitalzym Suggested Use for further guidance.
Vitalzym Original Formula
Other ingredients: Rice extract, Vegetarian Capsules (Cellulose, water).
Vitalzym is natural. It contains no animal derivatives, artificial flavors, artificial colors, yeast or gluten. Vitalzym is also lactose free and contains no harmful talc. The serrapeptase is prepared in such a way that it dissolves in your intestines, not in your stomach, and it operates in an extremely wide pH range, allowing for better absorption.
Suggested Use: As a dietary supplement, take 3 capsules, 1 to 3 times daily. Take capsules at least 30 minutes before a meal, 60 minutes after a meal, or any time in-between meals. Or, take an activation dose as recommended by a healthcare professional. Read Vitalzym Suggested Use for further guidance. Keep in mind that the suggested dosage of original Vitalzym is twice that of new Vitalzym.
Manufactured by World Nutrition, Inc. World Nutrition’s products are USP grade (United States Pharmacopeia). USP is a publication established in 1820 that contains legally recognized standards of identity, strength, quality, purity, packaging, and labeling for drug substances, dosage forms, and other therapeutic products, including nutritionals and dietary supplements.
WARNING: DO NOT take this product without the consent of your physician if you are lactating, or currently taking prescription anti-coagulants (blood thinners). As always, you should consult with a health care professional and/or pharmacist if you are taking prescription medications and would like to include dietary supplements into your regimen.
If you are pregnant consult with a doctor prior to using. If you are pregnant and have uterine fibroids, do not take Vitalzym. If you have bleeding ulcers or are a hemophiliac avoid using Vitalzym. Discontinue use two weeks prior to surgery.
Note: During the detoxification process, medications that have been stored in the liver may cause one to experience side effects that are related to its use and would not be considered a side effect from Vitalzym. Please talk with a health care professional if you feel you may be having symptoms that are unrelated to detoxing. Additionally, Vitalzym can increase the effectiveness of certain medications; another reason to consult with a doctor or pharmacist prior to using them if taking prescription drugs. Detoxification effects that can occur when taking Vitalzym can include heart palpitations for some individuals. If this occurs, you can reduce your dose to minimize the cleansing response. If you do experience heart palpitations that you feel may be unrelated to detoxing, please consult with a health care professional.
Manufactured by World Nutrition, Inc. Vitalzym passes USP (United States Pharmacopeia) testing for disintegration and dissolution. USP is a publication established in 1820 that contains legally recognized standards of identity, strength, quality, purity, packaging, and labeling for drug substances, dosage forms, and other therapeutic products, including nutritionals and dietary supplements.
Proteolytic enzyme (Protease)
The term "proteolytic" refers to all enzymes that digest protein. Other classes of enzymes include Amylase a digestive enzyme that breaks down carbohydrates and Lipase a digestive enzyme that breaks down fat during the digestive process. Each of these help in the digestion of food which in turn helps with absorption of those essential nutrients in the diet. In the body, proteolytic digestive enzymes are produced in the pancreas, but supplemental forms of enzymes may come from fungal or bacterial sources, extraction from the pancreas of livestock animals (trypsin/chymotrypsin) or extraction from plants (such as papain from the papaya and Bromelain from pineapples). The primary uses of proteolytic enzymes in dietary supplements are used as digestive enzymes, anti-inflammatory agents and pain relievers.
There are a number of clinical trials showing the benefits of using oral proteolytic enzymes as a digestive aid. Proteolytic enzymes are also theorized to help reduce symptoms of food allergies and as a treatment for rheumatoid arthritis and other autoimmune diseases
Perhaps the strongest evidence for benefits of proteolytic enzyme supplements come from numerous European studies showing various enzyme blends to be effective in accelerating recovery from exercise and injury in sportsmen as well as tissue repair in patients following surgery. In one study of footballers suffering from ankle injuries, proteolytic enzyme supplements accelerated healing and got players back on the field about 50% faster than athletes assigned to receive a placebo tablet(1). A handful of other small trials in athletes have shown enzymes can help reduce inflammation, speed healing of bruises and other tissue injuries (including fractures) and reduce overall recovery time when compared to athletes taking a placebo(2-8). In patients recovering from facial and various reconstructive surgeries, treatment with proteolytic enzymes significantly reduced swelling, bruising and stiffness compared to placebo groups (9-11).
Serrapeptase, also known as Serratia peptidase, is a proteolytic enzyme isolated from the non-pathogenic enterobacteria Serratia E15. The enzyme is found naturally in the intestine of the silkworm, which is used by the silkworm to dissolve the cocoon and emerge as a moth. The enzymes are then extracted from the medium so that not a trace of fungus is left on the enzyme and the purity is assured.
Serrapeptase has many clinical uses including:
The late German physician, Dr. Hans Nieper, used serrapeptase to treat arterial blockage in his coronary patients. Clinical studies show that serrapeptase induces fibrinolytic, anti-inflammatory and anti-edemic (prevents swelling and fluid retention) activity in a number of tissues, and that its anti-inflammatory effects are superior to other proteolytic enzymes(12).
Serrapeptase's most profound benefits, in addition to reducing inflammation, is reduction of pain, due to its ability to block the release of pain-inducing amines from inflamed tissues(13). Physicians throughout Europe and Asia have recognized the anti-inflammatory and pain-blocking benefits of this naturally occurring substance and are using it in treatment as an alternative to salicylates, ibuprofen, and other NSAIDs(14).
Both Bromelain and Papain are plant derived proteolytic enzymes. Bromelain, also known as bromelin, is a protein-digesting enzyme extracted from the flesh and stem of the pineapple plant, Ananas comosus. Papain, is a proteolytic enzyme isolated from the papaya plant, Carica papaya. Bromelain is most notable for its effectiveness in the reduction of inflammation and decreasing swelling, but the scope of its benefits continues to increase. As a natural anti-inflammatory enzyme, bromelain has many uses. Arthritis patients may reduce the swelling that causes joint pain by taking bromelain. Bromelain may also be helpful for the pain, numbness, tingling, aching, and loss of motor and sensory function in the fingers resulting from carpal tunnel syndrome (CTS) (15,16). Prevention of the adhesiveness of platelets to endothelial cell walls was accomplished with 0.1 mcg/ml of Bromelain(16a). Thus the benefit of bromelain occurs over a broad range of doses, and even small amounts may be beneficial to anyone at risk to thrombotic heart attack or stroke. Papain has been shown to be effective in preventing burn wound infection and helping remove dead cells(17). Papain is also used for the following:
Papain has been used to treat ulcers, dissolve membranes in diphtheria and reduce swelling, fever and adhesions after surgery.
Also known as Indian gooseberry (Emblica officinalis) is the richest source of Vitamin C. It also contains tannic acid, glucose, protein, cellulose and Calcium. Amla is useful for stomach problems, it is antipyretic, hair tonic and nerve brain tonic. It's also useful in anemia, hyperacidity and in gynecological problems and epistaxis. Amla is considered to have restorative and preventive properties.
Is one of the many existing Flavonoids. Flavonoids are a class of water-soluble plant pigments. Flavonoids support health by strengthening capillaries and other connective tissue, and some function as anti-inflammatory, antihistaminic, and antiviral agents. Rutin and several other flavonoids may also protect blood vessels. Rutin was shown to stimulate wound healing in rats and augment the tensile strength of scar tissue significantly(18).
1. Buck JE, Phillips N. Trial of Chymoral in professional footballers. Br J Clin Pract.1970 Sep;24(9):375-7.
2. Craig RP. The quantitative evaluation of the use of oral proteolytic enzymes in the treatment of sprained ankles. Injury. 1975 May;6(4):313-6.
3. Fisher JD, Weeks RL, Curry WM, Hrinda ME, Rosen LL. Effects of an oral enzyme preparation, Chymoral, upon serum proteins associated with injury (acute phase reactants) in man. J Med. 1974;5(5):258-73.
4. France LH. Treatment of injuries with orally administered Varidase as compared to Chymoral and Tanderil. Praxis. 1968 May 14;57(19):683-5.
5. Gal P, Tecl F, Skotakova J, Mach V. Systemic enzyme therapy in the treatment of supracondylar fractures of the humerus in children. Rozhl Chir. 1998 Dec;77(12):574-6.
6. Hingorani K. Oral enzyme therapy in severe back pain. Br J Clin Pract. 1968 May 5;22(5):209-10.
7. Rathgeber WF. The use of proteolytic enzymes (chymoral) in sporting injuries. S Afr Med J. 1971 Feb 13;45(7):181-3.
8. Schwinger O. Results of oral enzyme therapy in wounds of muscles, tendons and bones after accidents. Wien Med Wochenschr. 1970 Sep 5;120(36):603-5.
9. Duskova M, Wald M. Orally administered proteases in aesthetic surgery. Aesthetic Plast Surg. 1999 Jan-Feb;23(1):41-4.
10. Hoernecke R, Doenicke A. Perioperative enzyme therapy. A significant supplement to postoperative pain therapy? Anaesthesist. 1993 Dec;42(12):856-61.
11. Lie KK, Larsen RD, Posch JL. Therapeutic value of oral proteolytic enzymes following hand surgery. Arch Surg. 1969 Jan;98(1):103-4.
12. Mazzone A, Catalani M, Costanzo M, Drusian A, Mandoli A, Russo S, Guarini E, Vesperini G. Evaluation of Serratia peptidase in acute or chronic inflammation of otorhinolaryngology pathology: a multicentre, double-blind, randomized trial versus placebo. J Int Med Res. 1990; 18(5):379-88.
13. Mazzone A, et al. Evaluation of Serratia peptidase in acute or chronic inflammation of otorhinolaryngology pathology: a multicentre, double blind, randomized trial versus placebo. J Int Med Res. 1990; 18(5):379-88.
14. Aso T et al. Breast engorgement and its treatment: Clinical effects of Danzen an anti-inflammatory enzyme preparation. The world of Obstetrics and Gynecology (Japanese). 1981; 33:371-9.
15. Petry, Judy J. "Nutritional supplements and surgical patients." AORN Journal (June 1997).
16. Kelly, G.S. "Bromelain: A Literature Review and Discussion of Its Therapeutic Applications." Alternative Medicine Review (November 1, 1996).
16a. Metzig, C et al Bromelain Proteases reduce human platelet aggregation in vitro, adhesion to bovine endothelial cells and thrombus formation in rat vessels in vivo. In Vivo 13 (1): 7-12 Jan-Feb 1999.
17. Starley, I. F.; Mohammed, P.; Schneider, G.; Bickler, S. W. The treatment of paediatric burns using topical papaya. Burns 1999 nov 25 (7) 636-9
18. Wilhelmi, G. Effect of O-(beta-hydroxyethyl)-rutiside on wound healing in the rat. J pharmacology 1979 19(2):82-85.