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Professional Strength Systemic Enzyme Supplement

from World Nutrition
(1 reviews)  

Size: 180 Liquid Gelcaps
Item: 1756
Weight: 0.60 lbs

VitalzymXe is the Professional version, and therefore pricing is not shown online. For PRICE and to ORDER, please do one of the following:

  • Description
  • Enteric Coating
  • Compare
  • Supplement Facts
  • Suggested Use
  • Reviews

VitalzymXe - Prescription Strength

  • HW-vegetarian
  • MG-gluten-free
  • ND-dairy-free
  • QG-non-gmo-icon

VitalzymXe is the Professional version, and therefore pricing is not shown online. For PRICE and to ORDER, please do one of the following:

Vitälzȳm XE Overview presented by Dr. Worden

New Professional Strength VitalzymXe

VitalzymXe is for professional use. It is nearly identical to Vitalzym Extra Strength, but it is TWICE as strong so you take less capsules. The blister pak differentiates it from Vitalzym Extra Strength's flip top can. You get 180 capsules with VitalzymXE and 360 capsules with Vitalzym Extra Strength. The price is the same, so you get the same amount of product for the same cost.

Enzymes are the Building Blocks of Life

Supplementation with systemic enzymes may help the body to more efficiently regulate its metabolism, thereby reducing the physiological effects of aging. VitälzymXe is a unique blend of powerful systemic enzymes designed to assist the body’s normal metabolic processes

Physicians in Europe and Asia have long prescribed systemic enzyme supplements to restore enzyme levels and promote natural healing. Combined with professional healthcare, proper diet, and exercise, VitälzymXe may help you to maintain proper enzyme levels and balance the body’s own repair mechanisms.

Enzyme Overview by Dr. Donese Worden, N.M.D.

Proprietary Blend

VitälzymXe is recommended by healthcare professionals worldwide. The unique blend of vegetarian enzymes, flavonoids and antioxidants has been formulated for 100% absorption in the small intestine.

Serrapeptase, a key ingredient in VitälzymXe, was originally discovered in Japan and is commercially produced there for health applications. It has been used as a substitute for animal-derived enzymes (such as chymotrypsin) because of its stronger effect of decomposing bradykinin. Bradykinin is a protein found in the body that causes an inflammatory response.

For all conditions or illnesses, see a healthcare professional for a full evaluation, diagnosis or treatment plan.

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Made in Japan Under Japanese Manufacturing Guidelines

VitälzymXe is regulated by the Pharmaceutical and Food Safety Bureau under the Ministry of Health, Labor and Welfare in Japan. This agency is the Japanese equivalent of the FDA of the United States Department of Health and Human Services. Since VitälzymXe is regulated in Japan, it must adhere to manufacturing requirements that are far more stringent than dietary supplements manufactured in the United States. Supplements manufactured in the United States are considered food grade, and thus are not regulated as stringently as in Japan.

Quality control requirements of a licensed manufacturing facility in Japan are considered the most hygienic of any industry. Extreme measures are taken to avoid any possibility of contamination. Precautions include clean rooms, dust particle control, and sophisticated air filtration systems. During frequent site facility inspections, the government inspects all laboratory equipment and safety measures. Each inspection must be passed in order to retain the export licensure.

World Nutrition is also required to notify the Japanese Pharmaceutical and Food Safety Bureau of any variance to the registered ingredient blend. Any blend change would require a new registration for export. Every batch of product must be inspected before and after mixing to test adherence to the registered blend. In addition, every lot of raw material received by our manufacturing facility must be tested independently of the supplier for safety, impurities, potency and accuracy. These records must be disclosed upon facility inspections.

These Japanese manufacturing guidelines unique to the manufacturing of VitälzymXe ensure that each and every capsule is of the utmost purity, potency and safety.

Why Buy Vitalzym from Energetic Nutrition?

  • We are an Authorized World Nutrition Retailer, and one of their largest worldwide retailers.
  • We receive a fresh supply of products every week, which is kept under climate control.
  • We have been in business since 1996, and a trusted website since 1997.
  • Order by 3pm PST and we'll ship the same day (exceptions may apply).
  • Our knowledgeable staff is available to answer your questions by phone, email, or live chat.
  • We are known for our excellent customer service and educational support.
  • We truly care about your health, and we really appreciate your business!

Why is Enteric Coating Necessary?

Enteric Coating - State of the Art Delivery SystemWhen taking a typical supplement, the capsule or tablet is swallowed and travels down the esophagus to the stomach. In the stomach, the tablet or capsule is churned and gyrated in the highly acidic digestive secretions with pH 1.0-4.0, for 45 minutes to 2 hours.

If there is anything left of the table or capsule (and its contents), it will be passed through the duodenum to the small intestine.

What determines enzyme effectiveness?

The effectiveness of any systemic enzyme is determined by the amount of activity level in the bloodstream after the enzyme has been absorbed from the small intestine. Systemic enzymes, whose activity is significantly reduced in an acidic environment, must be protected from it for their utmost effectiveness.

Some enzymes will begin to lose their activity once introduced into the low pH (1.0-3.0) acids of the stomach. The amount of activity loss is dependent upon the individual enzyme and the amount of time it spends in the stomach.

What happens to uncoated tablets and capsules?

Stomach acid breaks down tablets and capsules to prematurely release active ingredients (enzymes). The highly acidic environment of the stomach destroys the majority of the enzymes' activities. If the tablet is of poor quality (contains binders and fillers) the product may pass through both the stomach and intestine with no absorption.

Studies have shown that certain unprotected enzymes can lose up to 100% of their activity in fewer than 30 minutes in pH levels below 3.0. The only reliable method of ensuring that 100% of the enzymes are not destroyed by the stomach acid is to enteric-coat the enzymes.

Delivery System Benefits

DuodenumLooking at the delivery system refers to how the enzymes are manufactured, whether it is a powder inside a capsule, a tablet, or as an enterically coated liquid gel—which is the most effective, state of the art delivery system on the market today.

Benefits of Enteric Coating

  1. Protects capsule or tablet contents from acidic environments of stomach.
  2. After passing through the stomach, it allows capsule or tablet to break down easily in pancreatic juices in the Duodenum* (pH 6-8).
  3. Enables absorption of enzymes, at their highest activity levels, in the small intestine.

Note: Not all enzymes are manufactured with enteric coating, and so often a premature release of certain enzymes can cause minimal if any absorption of the ingredients in the bloodstream where they belong.

*(approximately 1st 10" of small intestine)

Vitalzym's Enteric Coating

Vitalzym Systemic Enzymes with Enteric CoatingVitalzym is formulated for use with an enteric coated gel capsule manufactured under pharmaceutical-grade guidelines.

Though revolutionary to nutritional systemic enzyme blends, this enteric coating process is similar to that used in today's most advanced products. The capsule has an all-natural shell barrier that allows it to withstand the extremely low pH levels found in the stomach. Once introduced to the pancreatic juices in the duodenum (upper small intestine), the shell barrier breaks down to release the enzymes it contains. The enzymes are then absorbed into the bloodstream through the lining of the small intestine.

The enteric coated gel capsule has been designed to pass both the USP (United States Pharmacopeia) and JP (Japan Pharmacopeia) disintegration tests for enteric coated capsules. Every batch is tested to ensure it meets the agency guidelines before exportation to the U.S.

Solubilized Liquid-Filled Gel Capsule

Vitalzym Enteric Coated CapsulesAt the center of the advanced delivery system is the Solubilized Liquid-Filled Gel Capsule used to enhance the absorption of Vitalzym. The technology of liquid-filled capsules is superior to that of capsules filled with powder because it uses low heat production, provides more uniform dose distribution, and prolongs enzyme activity.

Low Heat Production – Powder enzyme blends are available today that use an enteric coating, but they are typically in tablet form. The disadvantage of these blends is the amount of heat created with compressing the ingredients into a tablet. Enzymes are susceptible to high temperatures and may begin to degrade during the manufacturing process. Solubilized Liquid-Filled Gel Capsules allow for an enteric coated enzyme without activity loss from heat. Throughout all of the processes, Vitalzym is produced under strictly controlled temperature ranges.

Optimal Distribution – Liquid enzyme blends provide a more uniform dose consistency, because the mixing of liquids allows for optimal particle distribution. In powder formulations, each particle of a different enzyme is different in size, causing greater friction between particles during mixing. Excipients are introduced to powder formulations to increase the mixability, but liquids still provide far more even distribution of ingredients, allowing for more consistent dosages in each capsule.

Prolonged Enzyme Activity – Enzymes always retain some amount of moisture when they are produced. Enzymes, as proteins, are more susceptible to denaturation at higher moisture. However, even with lower moisture, enzyme powders will lose some of their activity over time, resulting in a loss of up to 20% of activity over a 12-month period.

Vitalzym contains enzymes with a higher degree of purity and less moisture that when combined with medium-chain triglycerides (MCT). It is then decompressed during the manufacturing process, which removes the moisture completely. As a result, the loss of enzyme activity over time due to moisture will not occur after Vitalzym is produced.

Vitalzym is manufactured to have a 5-year shelf life with no loss of activity when properly stored in a cool, dry place with the lid tightly closed.

Enzyme Delivery System Comparison

Over the years, there have been various methods of enteric coating to help protect the enzymes that can be destroyed by stomach acid and some have been proven to be more effective than others. As you will see, the latest technology of enteric coating has been used to protect the enzymes in Vitalzym.

VitälzymXe Enteric Coated Liquid Filled Gel Capsule

VitalzymXe Enteric Coated Liquid-Filled Gel Capsule and Enzyme Absorption The all natural protective coating of Vitalzym XE prevents the enzymes from being destroyed by the stomach acids. The pancreatic juices break down the coating in the duodenum. This makes 100% of the enzyme contents available for absorption into the bloodstream.

Powder-Filled Capsule, Vegetarian or Gelatin

Powder Filled Capsule and Enzyme Absorption Powder filled capsule technology is suitable for contents that are not susceptible to the acidity of the stomach. The capsule and its enzyme are dissolved prematurely in the stomach, resulting in up to 100% destruction of the enzymes within 30 minutes in the extremely low pH environment.

Enteric Coated Tablet

Enteric Coated Tablet and Enzyme Absorption Enteric coated tablets are able to withstand stomach acids; however they must be introduced into a high pH environment for extended periods before dissolving. Since individual pH levels vary, the tablet may dissolve very late in the small intestine or bypass it completely. Many users also complain of the synthetic coating.

Are You Choosing the Right Enzyme Product?

Stomach acid breaks down tablets and capsules to prematurely release the active ingredients of an enzyme formula, such as Vitalzym. The highly acidic environment of the stomach can destroy the majority of enzymes activities.

Additionally, if the tablet is of poor quality (contains binders and fillers), the product may pass through both the stomach and intestines with no absorption. Unfortunately, the effectiveness of an enzyme is determined by the amount of activity level in the bloodstream after the enzyme has been absorbed from the small intestine.

Enzymes lose activity in low pH (1-3) of the stomach. Studies show unprotected enzymes can lose up to 100% of their activity in 30 minutes or less! Therefore, the only reliable method is to ensure 100% of the enzymes are not destroyed is to enteric coat the enzymes.

Lab Results and Research Testing

Testing reveals how enzymes withstand different acidic areas of the body as it passes from the mouth, down the esophagus, into the stomach, through the duodenum and small intestine, and finally finds its way into the bloodstream.

Residual Activity vs pH

Several laboratory tests have demonstrated the effectiveness of a fully enteric-coated systemic enzyme product, as more available to be absorbed into the bloodstream through the small intestine, than other enzyme delivery systems.

The following tests demonstrate, that of the products tested, only the fully-enteric-coated product maintains its full activity level after passing through the acid of the stomach.

These tests were conducted under laboratory conditions by Japan Food Research Laboratories, an independent government laboratory authorized by the Japanese government. The tests are only intended to show the likely results of the loss of enzyme activity levels on various enzyme products when those products are subjected to simulated common stomach acid conditions. The actual enzyme activity levels of these products, when absorbed into the bloodstream, may vary based on your own body's metabolism and pH level.

Disintegration and Dissolution Test: To determine the availability of enzyme activity after passing through the stomach acid for the fully enteric-coated systemic enzyme product, Vitalzym. The "Disintegration Test (Enteric-coated capsule)", was performed in accordance with the Japanese Pharmacopoeia, Seventh and Fifteenth Editions. This test simulated the acid conditions of the stomach and tested for the disintegration of the sample capsules within a prescribe time period. In the case of Vitalzym, the test result indicated that the product conformed to acceptable test criteria.

For products that did not pass the test criteria, the following Protease Activity Loss Tests were performed to determine the actual amount of enzyme loss in the simulated conditions.

  1. Neutral Protease Activity Test: A sample of each enzyme product was tested in a neutral state (100% activity) utilizing a standard protease activity assay method.
  2. Protease Activity Test: A sample of each enzyme product was then tested utilizing the same test procedure after being exposed to the simulated acid condition of the stomach.

While Vitalzym passed the enteric coating test, the following table illustrates the activity losses for the other systemic enzyme products tested:






 Beginning Enzyme Activity
 100%  100%  100%  100%

 Activity LOSS

 87.84%  92.09%  97.44%  97.52%

Taking enteric coated Vitalzym can be an effective way to insure that the enzymes in this formula reach the small intestine where they can be absorbed into the bloodstream in order to obtain the utmost effectiveness.

**Neprinol® and Serracel® are registered trademarks of Arthur Andrew Medical; Exclzyme® and Serracor®are registered trademarks of Specialty Enzymes and Biochemicals Co.; none of whom are affiliated with, nor sponsor or endorse these products or any other product from companies mentioned in this site. The names of all other companies, products and services are the property of their respective owners.

Compare Vitalzym Products

Vitalzym Product Comparison Chart

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Compare Vitalzym Products

Vitalzym is a trusted name in systemic enzyme supplementation. World Nutrition has produced extremely popular enzyme formulas for years, and now they bring you the latest technology in enzyme production with Vitalzym Extra Strength.

Other Vitalzym Products Available

Vitalzym Extra Strength
Professional Strength

Vitalzym Extra Strength

Original Vitalzym
The Original Vitalzym Formula

Original Vitalzym

Cardiovascular Formula


Supplement Facts - VitalzymXe

All Natural • Non-Toxic • Non-GMO • Vegetarian Formula

Capsules per container 180
Serving size Three (3) capsules
Servings per container 60
Amount per serving 324 mg **

** Daily Value not established. Mg measures weight, not potency of quantity of ingredients.

Click HERE to see full label.

Proprietary blend contains: Bromelain, papain, rutin, amylase, protease, lipase, serrapeptase, and amla extract.

Other ingredients: Medium-chain triglycerides, starch, glycerin, polysaccharides, pH resistant enteric coating, beeswax, glycerin fatty acid ester, riboflavin, soy lecithin*, and citric acid.


Warning: If you are currently taking prescription drugs, consult your healthcare professional prior to use.

*The soy lecithin acts an emulsifier, and is only in trace amounts - less than 1% of the entire product. Testing of soy lecithin has confirmed that no phytoestrogens are delivered to the body, and therefore there is no impact on hormones. People with a soy allergy have never reported any issues with Vitalzym capsules.

VitalzymXe is natural and 100% vegetarian. It contains no artificial flavors, artificial colors, yeast or gluten. VitalzymXe is also lactose free and contains no harmful talc.

Manufactured in Japan for World Nutrition, Inc. VitalzymXe passes both the USP (United States Pharmacopeia) and JP (Japan Pharmacopeia) testing for disintegration and dissolution. USP is a publication established in 1820 that contains legally recognized standards of identity, strength, quality, purity, packaging, and labeling for drug substances, dosage forms, and other therapeutic products, including nutritionals and dietary supplements. Every batch is tested to ensure it meets the agency guidelines before exportation to the U.S.

World Nutrition, Inc. is Committed to Providing Customers with Safe Products

World Nutrition, Inc. currently imports three products from Japan: Extra Strength Vitalzym, VitalzymXe Professional Strength, and Ketsumeisei.

Original Vitalzym is manufactured in the United States.

With concerns arising from the 2011 natural disasters in Japan, we want to inform our customers that World Nutrition, Inc. is committed to ensuring that none of the products we ship to our customers are contaminated with radiation.

The following statement is from World Nutrition:

Our manufacturing facility in Japan is located in Shizuoka which is on the southwest side of the island, approximately 250 miles away from where the affected power plant is located. This location brings with it a completely different supply of groundwater. It also has the benefit of having the massive natural barrier of Mt. Fuji, thus defending against the slightest chance of air flow and weather patterns having any effect. This is true especially as the weather moves from west to east – taking any polluted air away from our facility instead of towards it.

More importantly we have numerous steps in place to validate its safety. All of our raw materials are tested upon arrival at our facility overseas. Once those ingredients have passed inspection, the product is manufactured and tested again. Once passed it is prepared for shipment. Our cartage company tests every single thing they carry from Japan, so it is tested again. Once passed, it is brought over to the US. Once it arrives, Customs tests it again. After it passes the FDA does their inspection and tests it again, since the product is registered as a food supplement. Once they pass and release it, the product goes to our fulfillment center. We have a lab that we work with here in Arizona where we send randomly pulled samples from our shipment for testing. Once they pass it, only then do we accept it into our inventory. It is a very costly and elaborate process, but once we have all 6 different validations of its safety – all from different independent sources – then we feel quite comfortable offering the product to our customers.

When we say "passed," we do not mean that it is deemed by a handful of people to be at a tolerable level… we mean it has come back with an reading of ZERO radiation.

If you have any further questions or concerns, please feel free to contact World Nutrition at 800-548-2710.

Suggested Use - VitalzymXe

As a dietary supplement, take 3 capsules daily, or as recommended by your healthcare professional. Take capsules at least 30 minutes before or after a meal, or any time in-between meals. Or, take an activation dose as recommended by a healthcare professional.

Read Vitalzym Suggested Use for further guidance.

Important Note: Though both Vitalzym and VitalzymXe state the suggest use is 3 capsules per day, VitalzymXe is about double the strength of new regular Vitalzym. It has been formulated as professional strength for therapeutic purposes. Three capsules of VitalzymXe is equivalent to 6 capsules of regular Vitalzym.

WARNING: DO NOT take Vitalzym without the consent of your physician if you are lactating or currently taking prescription anticoagulants (blood thinners). As always, you should consult with a health care professional and/or pharmacist if you are taking prescription medications and would like to include dietary supplements into your regimen.

  • If you are pregnant, consult with a doctor prior to using.
  • If you are pregnant AND have uterine fibroids, do not take Vitalzym.
  • If you have bleeding ulcers, or are a hemophiliac, avoid using Vitalzym.
  • Discontinue use two weeks prior to surgery.
  • Anyone who has ever suffered intracranial (brain) bleeding, or who has had neurosurgery or ischemic stroke in the previous six months, should avoid these enzymes.
Caution Regarding Serrapeptase

Not everyone should take Serrapeptase. This includes:

  • People with bleeding disorders, such as hemophilia or a group of diseases called "hemorrhagic diathesis", should not use this natural product.

  • People with ongoing bleeding problems, including ulcers, recent surgery, recent major trauma, or hemorrhoids also should not use serrapeptase.

  • Those with severe uncontrolled high blood pressure should also refrain from taking nattokinase and serrapeptase.
Detoxification Effects

During the detoxification process, medications that have been stored in the liver may cause one to experience side effects that are related to its use and would not be considered a side effect from Vitalzym.

Please talk with a health care professional if you feel you may be having symptoms that are unrelated to detoxing. Detoxification effects that can occur when taking Vitalzym can include heart palpitations for some individuals. If this occurs, you can reduce your dose to minimize the cleansing response. If you do experience heart palpitations that you feel may be unrelated to detoxing, please consult with a health care professional.

Medication Interactions

Additionally, Vitalzym can increase the effectiveness of certain medications; another reason to consult with a doctor or pharmacist prior to using them if taking prescription drugs.

Side Effects

Dr. Cichoke says, "There appear to be no side effects of long-term duration when taking oral enzymes. Temporary side effects (that will disappear when therapy is discontinued or reduced); include changes in the color, consistency, and odor of the stool. Gastrointestinal disturbances, such as flatulence, a feeling of fullness, diarrhea, or nausea, may occur in individual cases, and minor allergic reactions (reddening of the skin) are rare and occur only with high doses." He also goes on to say that no detriment has been associated with long term usage of supplemental enzymes and best results can be seen when doses are divided throughout the day rather than taken all at one time.1


1. Cichoke Enzymes and Enzyme Therapy, (Keats Publishing, Chicago, IL, 2000)


Average customer rating:
(1 reviews)  

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1 Most recent customer reviews (see all reviews):
Ms. Dana Lindsey
Jun 3, 2015
This customer purchased the item at our site.
Sometimes you buy things because they claim it's the miracle cure, but you continue buying it because it works. I had done some research on enzymes prior to hearing about VitalzymXe, but to get the different enzymes I need at the strength I need, would have been insanely expensive. I know when you look at this price, you think $140 is insane, but you don't need anything else and once you get healed and your just maintaining, this will last you 3-4 months. I'm not trying to sell anyone else on this, I'm just sharing my experience.

I knew it worked when I had to walk for several miles up and down hills in high heel shoes. I just knew I was going to pay the next day. But the next day I got up and felt no pain. That wouldn't have happened before. Now that my body is getting what it needs, it gives me what i need. Try it once, you'll see.
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† These statements have not been evaluated by the U.S. Food and Drug Administration (FDA) or This product is not intended to diagnose, treat, cure or prevent any disease. The information provided on this site is for informational purposes only and is not intended as a substitute for advice from your physician or other health care professional or any information contained on or in any product label or packaging. You should not use the information on this site for diagnosis or treatment of any health problem or for prescription of any medication or other treatment. You should consult with a health care professional before starting any diet, exercise or supplementation program, before taking any medication, or if you have or suspect you might have a health problem, or are pregnant. When you receive an item, carefully read all labels, warnings, and directions before use. Actual product packaging and materials may contain more and/or different information than shown on this website.

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