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Home > Vitalzym > About Systemic Enzymes

About Systemic Enzymes

And What They Can Do

Enzymes are proteins that act as catalysts for millions of chemical reactions within the body. Nearly all processes in the body, from breaking down food to healing from an injury, require enzymes. Enzymes are used for the building, maintenance and repair of every cell of the body. There are three primary types of enzymes:

    1. Digestive enzymes, which are taken with food to assist in digestion and nutrient absorption.
    2. Food enzymes, found naturally in raw and lightly cooked food.
    3. Systemic enzymes, which are taken to support health and repair of the body. Vitalzym is a systemic enzyme.

Though our body produces enzymes naturally, many health care experts now believe that our natural enzyme production begins to decline after age 25. As we age, our body produces fewer enzymes, and eventually we become enzyme deficient. This is when many people begin to notice the effects of aging, including joint pain and circulatory problems, slower injury and wound healing, and increased internal inflammation and disease.

Supplementing with systemic enzymes will help to build and maintain health. Because our bodies natural production on enzymes begins to wane in early adulthood, most people would likely benefit from supplementing with systemic enzymes. Whether taking Vitalzym to help address a specific condition, or to simply promote prevention and better overall health, supplementing with enzymes will provide your body with the additional support it needs to thrive.

Using Systemic Enzymes as a Natural Anti-Inflammatory

Enzymes vs. NSAIDs to Manage Inflammation:

InflammationNon-steroidal anti-inflammatory drugs (NSAIDs), commonly found in asprin, advil, and other anti-inflammatory drugs, can be helpful to reduce inflammation temporarily, but often cause more harm than good. NSAIDs have been shown to suppress the production of ALL circulating immune complexes, some of which are needed to maintain balance in the body.

Systemic enzymes on the other hand, are able to keep the balance of circulating immune complexes in check by aiding in the production of beneficial killer cells and CIC's and then by helping the liver properly dispose of the toxins. When the immune system is overburdened with the production and removal of circulating immune complexes, these CIC's can build up and become trapped in the tissues of the body and set off a reaction that leads to inflammation, pain and tissue damage.

According to the American Gastroenterological Association, NSAIDs hospitalize over 100,000 people and kill thousands in the U.S. each year. Systemic enzymes, on the other hand, are a safe and effective alternative, and have NO LD-50, or, toxic dose, and do not create side effects like those associated with NSAIDs.

Serrapeptase for Inflammation:

Serrapeptase has proven to be one of the strongest and most effective proteolytic enzymes able to break down fibrin and reduce inflammation. Clinical studies show that Serrapeptase, a key ingredient in Vitalzym, induces fibrinolytic, anti-inflammatory and anti-edemic (prevents swelling and fluid retention) activity in a number of tissues, and that its anti-inflammatory effects are superior to other proteolytic enzymes.(1)

Besides reducing inflammation, one of Serrapeptases most profound benefits is reduction of pain, due to its ability to block the release of pain-inducing amines from inflamed tissues.(2) Physicians throughout Europe and Asia have recognized the anti-inflammatory and pain-blocking benefits of this naturally occurring substance and are using it in treatment as an alternative to salicylates, ibuprofen and other NSAIDs.(3)

Enzymes for Internal Inflammation:

We are all familiar with the pain and inflammation that occurs when we are injured, have an infection, or have had surgery. Not many people, however, are actually familiar with the body's internal inflammatory process that occurs within each of our bodies. This internal inflammation can have a significant effect on the state of our health, leading to a variety of serious conditions and diseases, It often goes unnoticed until it is too late. Internal inflammation most often comes from undiagnosed food allergies, excess weight, yeast and bacterial overgrowths, unaddressed infections and chronic high cortisol levels, usually caused by chronic high stress.

According to an article in the New York Times titled Body's Defender Goes on the Attack, "Scientists are coming to realize that inflammation may underlie many other common chronic diseases that come with aging, including atherosclerosis, diabetes, Alzheimer's disease and osteoporosis. Inflammation is also implicated in asthma, cirrhosis of the liver, some bowel disorders, psoriasis, meningitis, cystic fibrosis, and even cancer." (10)

The New York Times article continues to say “two large studies -- one in men and one in women -- have demonstrated that the higher a person's C-reactive protein (CRP) level, the greater the risk of a heart attack or stroke." 

C-reactive protein is produced by the liver and is a clinical marker of general and/or cardiac-related inflammation. When internal inflammation is present, CRP levels can rise.

Read More on our Blog
arrow Inflammation May Underlie Many Chronic Diseases
arrow You’re All Heart - Cardiovascular Health in Women!

In Yahoo Health's article: Inflammation: The Root Cause of All Disease?, Philip Schauer, MD, director of the Bariatric and Metabolic Institute at the Cleveland Clinic, is quoted as saying "There are clear indications that inflammation explains why plaque builds up in the arteries in patients with atherosclerosis.Chronic inflammation also plays a direct role in diabetes, high blood pressure, sleep apnea, asthma and many other conditions." The article goes on to explain that the #1 warning sign of chronic inflammation is excessive visceral fat, ie excess fat around the waist.

Systemic enzymes such as Vitalzym and Vitalzym Cardio can be helpful for reducing inflammation because they are able to break down the proteins (CICs) responsible for causing the inflammation. What is more impressive is that enzymes are able to identify useful proteins from foreign or exogenous proteins, which are the proteins that can contribute to health problems.

Systemic Enzymes for Anti Fibrosis and Scar Tissue

Systemic enzymes can be helpful for fibrosis conditions in the body as fibrosis conditions are caused by a hard, sticky protein called fibrin. Enzymes are able to break down fibrin and reduce the development of excess fibrin in the body. Fibrosis of the organs in particular can cause particular health challenges. As fibrin collects in our organs, it can cause a hardening and shrinking of the organ tissue, eventually leading to poor organ function and possibly failure. As we age, fibrin tends to build up in our body and can contribute to a variety of conditions including:

  • Fibrosis of the organs (6)
  • Scar tissue including endometriosis (6)
  • Slow wound healing
  • Hardening of the arteries leading to heart problems (7)
  • Blood clots/thickening of the blood (4)
  • Fibromyalgia symptoms
  • Multiple Sclerosis (8)
  • Asthma (9)
  • Uterine fibroid tumors

When we supplement with enzymes, it helps to break down fibrin before it deposits and builds up in our organs, tissue and blood.

Scar tissue is also made up of fibrin. Vitalzym contains a highly concentrated amount of the enzyme Serrapeptase, which has shown to be exceptionally effective for breaking down fibrin. Therefore, supplementing with Vitalzym can help to break down the fibrin, thus reducing scar tissue and the discomfort associated with scar tissue.

Read More on our Blog
arrow Did you know that 20-50% of women of childbearing age have uterine fibroids?
arrow The Role of Fibrin in Fibromyalgia Pain
arrow Fibromyalgia Syndrome – Getting Started on the Restoration Action Plan
arrow Fibromyalgia Affects an Estimated 10 Million People in the U.S.

Systemic Enzymes and Blood Cleansing

Enzymes like those in Vitalzym Cardio support wellness by cleaning up the blood. The blood is the highway through which nutrients, as well as toxins and cellular waste, travel to reach their final destinations. When the waste and toxins are not adequately cleared out, often due to lack of enzymes and sluggish liver function, they get recycled in the blood, creating a sort of "traffic jam of the vital detoxification pathways," which can contribute to inflammation and poor health. Enzymes are able to keep the highway clear and traffic free by reducing excess or harmful circulating immune complexes, cellular debris, and toxins in the blood that may be contributing to viruses, allergies, and fatigue.

When systemic enzymes are taken, they stand ready in the blood and take the strain off of the liver by:

  • Cleaning excess fibrin from the blood and reducing the stickiness of blood cells. These two actions minimize the leading causes of stroke and heart attack: blood clots. (4)

  • Breaking cellular waste and toxin material down small enough that it can immediately pass into the bowel. (4)

  • Cleansing the FC receptors on the white blood cells, improving their function and availability to fight off infection. (5)

And here we come to the only warning we have to give concerning the use of Vitalzym or any other systemic enzyme - don't use the product if you are a hemophiliac or are on prescription blood thinners like coumadin, heparin and plavix without talking to your doctor. The enzymes cause the drugs to work better, so there is the possibility of thinning the blood too much.

Systemic Enzymes for Immune System Modulation and Virus Fighting

Enzymes are extremely effective in supporting immune function.Further, enzymes are adaptogenic, seeking to restore a steady state to the body (5). When the immune system is running low, we become susceptible to infectious disease. Vitalzym increases immune response, producing more Natural Killer cells, and improving the efficiency of the white blood cells, all leading to improved immunity.
Read More on our Blog
arrow A Strong Immune System Can Help Fight Flu Viruses

When it's cranked up too high, then the system creates antibodies that attack it's own tissues, as are seen in the autoimmune diseases of Multiple Sclerosis, Rheumatoid Arthritis, and Lupus. In this case, Vitalzym will tone down immune function and eat away at the antibodies the immune system is making to attack its bodies own tissue.

According to Tom Bohager, author of Everything You Need to Know About Enzymes:

"The immune system's ability to fight off invaders depends on the enzyme protease, which breaks down proteins. Most types of illnesses are in some way related to protein. For example, cancer cells are surrounded by the protein fibrin. The blood clots that cause stroke and a high percentage of heart attacks are made up of this same protein. Pathogenic bacteria and parasites are comprised of proteins. Viruses are enveloped by protein, and fungal forms such as Candida contain a protein nucleus surrounded by a chitin shell. Therefore, we need a plentiful supply of protease to overcome protein invaders in the body that will make us ill if left unchecked."

Systemic Enzymes for Managing Yeast Overgrowth

Read More on our Blog
arrow Taming the Yeast Beast – A Natural Guide to Getting Rid of Candida for Good
Yeast organisms like Candida Albicans are single-celled organisms that naturally reside in the intestinal tract. Normally, they do no harm, because they are kept in check by beneficial bacteria (probiotics) like acidophilus and bifidus. When yeast overgrows, however, it can create a wide variety of symptoms including:
  • Digestive distress, gas and bloating
  • Fatigue/lethargy
  • Weakened immune system
  • Brain fog or trouble focusing
  • Craving sweets
  • Anxiety/panic attacks
  • Rectal itching
  • Skin rashes
  • Acne
  • Sore throat

Vitalzym can help manage yeast and keep it under control because it is actually able to break down the cell wall of the yeast. Further, yeast can cause problems by releasing toxins into the blood stream that can not only cause discomfort, but also put stress on the liver. Vitalzym supports optimal liver function and detoxification, and will help to ensure your body is able to metabolize and excrete the toxins that yeast creates as it dies off.


1. Mazzone A, Catalani M, Costanzo M, Drusian A, Mandoli A, Russo S, Guarini E, Vesperini G. Evaluation of Serratia peptidase in acute or chronic inflammation of otorhinolaryngology pathology: a multicentre, double-blind, randomized trial versus placebo. J Int Med Res. 1990; 18(5):379-88.

2. Mazzone A, et al. Evaluation of Serratia peptidase in acute or chronic inflammation of otorhinolaryngology pathology: a multicentre, double-blind, randomized trial versus placebo. J Int Med Res. 1990; 18(5):379-88.

3. Aso T et al. Breast engorgement and its treatment: Clinical effects of Danzen an anti-inflammatory enzyme preparation. The world of Obstetrics and Gynecology (Japanese). 1981; 33:371-9.

4. Ernst E., Matrai A.: Oral Therapy with proteolytic enzymes for modifying blood rheology. Klin Wschr. 65 (1987), 994.

5. Kunze R., Ransberger K., et at: Humoral immunomodulatory capacity of proteases in immune complex decomposition and formation. First International symposium on combination therapies, Washington, DC, 1991.

6. Kakinumu A. et al.: Regressing of fibrinolysis in scalded rats by administration of serrapeptase. Biochem. Pharmacol. 31:2861-2866, 1982.

7. Eidelman RS, Hennekens CH. Fibrinogen: a predictor of stroke and marker of atherosclerosis. Eur Heart J. 2003;24:499-500.

8. 27. Sobel RA, Mitchell ME. Fibronectin in multiple sclerosis lesions. Am J Pathol. 1989;135:161-168.

9. 28. Gveric D, Hanemaaijer R, Newcombe J, van Lent NA, Sier CF, Cuzner ML. Plasminogen activators in multiple sclerosis lesions: implications for the inflammatory response and axonal damage. Brain. 2001;124(Pt 10):1978-1988.

10. New York Times article, Body’s Defender Goes on the Attack

Why buy Vitalzym from Energetic Nutrition?

  • We are an Authorized Vitalzym Retailer, and one of their largest worldwide retailers.
  • We receive a fresh supply of Vitalzym every week, which is kept under climate control.
  • We have been in business since 1996, and a trusted website since 1997.
  • Order by 3pm and we will ship the same day (exceptions may apply).
  • Our excellent staff is available to answer your questions by phone, email, or live chat.
  • We are known for our excellent customer service and educational support.
  • We truly care about your health, and we really appreciate your business!

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