USD ($)
  • Select currency:
Register Customers Only Offers
1-888-501-3344        LIVE CHAT
9am to 5pm PST / Monday-Friday
Compare up to 4 items:
  • compare item
  • compare item
  • compare item
  • compare item
Mushroom Immune Defense
Mouse over or click to enlarge

Mushroom Immune Defense

16 Mushroom Immunity Complex from Source Naturals
(0 reviews)  

Retail $27.50
 you save 45%
Size: 60 Tablets - 1,025 mg
Item: 5660
Weight: 0.33 lbs
Points: 75
Mushroom Immune Defense features 16 of the best-studied species of health-supportive mushrooms, including shiitake, reishi, and maitake. Researchers propose that constituents of these mushrooms may support natural killer (NK) cell, T-cell, macrophage activity, and cytokine production all of which are necessary for proper immune function.

  • Description
  • Supplement Facts
  • Reviews

Mushroom Immune Defense™ features 16 of the best-studied species of health-supportive mushrooms, including shiitake, reishi, and maitake. These mushrooms contain compounds, including beta-glucans, glycoproteins and polysaccharides, which support a wide range of immune defenses.

Researchers propose that constituents of these mushrooms may support natural killer (NK) cell, T-cell, macrophage activity, and cytokine production all of which are necessary for proper immune function. Supplementing with Mushroom Immune Defense may be especially important these days with more dangerous strains of cold and flu that seem to be surfacing.

The Immune System

The immune system is a complex network of specialized tissues, organs, cells, and biochemicals.

Innate immunity is present at birth and provides the first line of defense. The skin, mucus secretions, and stomach acidity are examples of innate immunity. Adaptive immunity is acquired later in life, and includes elements such as antigens that generate antibodies, or white blood cells, T-cells, and B-cells. Amazingly, the adaptive immune system retains a memory of all its activities.

Boost Your Immune System During the Winter Season

Advanced Nutrition: Beta-Glucan

Beta-glucan is a complex sugar (polysaccharide) derived from the cell wall of baker’s yeast, oat and barley fiber, and many mushrooms.  Beta-glucans bind to receptor sites on macrophages and neutrophils, which are part of the immune system’s first line of defense. This nutrient has been widely researched for its immune-supportive properties.

How Do Mushrooms Work?

Mushrooms are a treasure trove of bioactive compounds, but most of their immunomodulating activities have been attributed to polysaccharides (long-chain, simple sugars) and glycoproteins (polysaccharides naturally associated with proteins). These compounds activate a variety of immune responses.

The following mushrooms have demonstrated the most evidence for immune defense:

Shiitake (Lentinula edodes): Lentinan, the beta glucan from shiitake, has been studied more extensively than similar substances and may be one of the most effective immunomodulators. Numerous studies have shown its ability to stimulate natural killer cell, T-cell, and macrophage-dependent responses.

Reishi (Ganoderma lucidum): Reishi’s polysaccharides may stimulate macrophages and enhance T-cell proliferation, according to in vitro studies.

Maitake (Grifola frondosa): Maitake enhances the activities of natural killer cells, T-cells and macrophages, according to animal studies. MUSHROOM IMMUNE DEFENSE contains MaitakeGold 404™, a highly specialized maitake product, rich in beta-glucans, which is the only maitake betaglucan fraction endorsed by the world’s premier maitake researcher, Dr. Hiroaki Nanba, Ph.D.

Turkey Tails (Trametes versicolor): These mushrooms have a long history of traditional use in Asia. One in vitro study suggests that its polysaccharides stimulate macrophages.

Almond portabella (Agaricus blazei): This mushroom may stimulate the immune system by increasing T-cell activity, according to animal studies.

Cordyceps (Cordyceps sinensis): Cordyceps came to international attention during National Games in China when, in one week, three women’s track and field world records were broken. The coach partially credited a cordyceps elixir.  Cordyceps was found to augment antibody and other immune responses in one animal study, and a cordyceps polysaccharide was found to elevate cytokines in vitro.

Mushroom Immune Defense contains 10 additional mushrooms, including enoke, oyster, Polyporus umbellatus, and Poria cocos. Vitamin C is added to enhance absorption and activity. By carefully combining these mushrooms and fortifying them with extracts, Mushroom Immune Defense offers a broad- spectrum, high potency, complete mushroom product.

Remember, a focus on immune support can pay tremendous dividends for your entire life. If you are dedicated to good health you want a powerful formula on your side, such as Mushroom Immune Defense.


Kurashige S, et al. 1997. Immunopharmacol Immunotoxicol 1997 19(2):175-83.

Wang S. Y. et al. 1994. Program and Abstracts of  the’94 International Symposium on Ganoderma Research. Beijing: Beijing Medical University.

Wasser S. P. and Weis A. L. 1999a. Crit Rev Immunol, 19, 65-96.

Sherwood ER, Williams DL, McNamme RB, Jones EL, Browder IW, Di Luzio NR. Enhancement of interleukin-1 and interleukin-2 production by soluble glucan.  Int J Immunopharmacol (1987) 9(3): 261-267.

Supplement Facts

Tablets per Container: 60 Tablets
Serving Size:  One (1) to Two (2) Tablets
Servings per Container:  30 to 60
Suggested Use: 1 to 2 tablests a day in between meals.

Supplement Facts for 1,025 mg Capsule
Serving Size: 2 tablet(s)
Amount per Serving % Daily Value
Calories 10  
Total Carbohydrates 2 g 1%
Vitamin C (as ascorbic acid) 100 mg 170%
Shiitake Mycelia Biomass 200 mg
Reishi Mycelia Biomass 200 mg
Maitake Mycelia Biomass 200 mg
Turkey Tail Mycelia Biomass 150 mg
Proprietary Blend: 1.3 g

Agaricus blazei Mycelia Biomass, Hericium rinaceous Mycelia Biomass, Flammulina velutipes Mycelia Biomass, Tremella Mycelia Biomass, Schizophyllum commiune Mycelia Biomass, Artist's Conk Mycelia Biomass, Poria Mycelia Biomass, Zhu Ling Mycelia Biomass, Pleurotus ostreatus Mycelia Biomass, Cordyceps sinensis celia Biomass, Cordyceps militaris Mycelia Biomass, Armilleria mellea Mycelia Biomass, Shiitake Mushroom Extract, Reishi Mushroom Extract, Maitake Mushroom Extract, Turkey Tail Mushroom Extract, Cordyceps sinensis CS-4 Standardized Extract (0.1% adenosine), Agaricus blazei Mushroom Extract, and Dr. Namba's Maitake Beta-Factor™ (beta-glucan) Fraction.

† Daily Value not established.

Other Ingredients: Stearic acid, colloidal silicon dioxide, and modified cellulose gum. Contains gluten.

Warning: If you are pregnant, may become pregnant, or breastfeeding, consult your health care professional before using this product.  Do not use if either tamper-evident seal is broken or missing. Keep out of the reach of children.

Manufactured by Source Naturals


There have been no reviews

Only registered customers are allowed to add review. Please sign in and add your own review!

† These statements have not been evaluated by the U.S. Food and Drug Administration (FDA) or This product is not intended to diagnose, treat, cure or prevent any disease. The information provided on this site is for informational purposes only and is not intended as a substitute for advice from your physician or other health care professional or any information contained on or in any product label or packaging. You should not use the information on this site for diagnosis or treatment of any health problem or for prescription of any medication or other treatment. You should consult with a health care professional before starting any diet, exercise or supplementation program, before taking any medication, or if you have or suspect you might have a health problem, or are pregnant. When you receive an item, carefully read all labels, warnings, and directions before use. Actual product packaging and materials may contain more and/or different information than shown on this website.

Recommended Products

Reviews from
Reseller Ratings

Reviews from
Shopper Approved

Shopper Approved - Comments from real customers!

Join our Health Newsletter and Sale Announcement