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Mushroom Immune Defense
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Mushroom Immune Defense

16 Mushroom Immunity Complex

from Source Naturals
Retail $28.50
 you save 30%
Size: 60 Tablets - 1,025 mg
Item: 5660
Weight: 0.25 lbs
Points: 99
Mushroom Immune Defense features 16 of the best-studied species of health-supportive mushrooms, including shiitake, reishi, and maitake. Researchers propose that constituents of these mushrooms may support natural killer (NK) cell, T-cell, macrophage activity, and cytokine production all of which are necessary for proper immune function.

  • Description
  • Supplement Facts & Suggested Use
  • Reviews

Mushroom Immune Defense™

  • HN-all-natural
  • HW-vegetarian
  • MW-wheat-free
  • ND-dairy-free
  • OS-soy-free
  • PY-yeast-free

Mushroom Immune Defense™ features 16 of the best-studied species of health-supportive mushrooms, including shiitake, reishi, and maitake. These mushrooms contain compounds, including beta-glucans, glycoproteins and polysaccharides, which support a wide range of immune defenses.

Researchers propose that constituents of these mushrooms may support Natural Killer (NK) cell, T-cell, macrophage activity, and cytokine production all of which are necessary for proper immune function.†

How Do Mushrooms Work?

Mushrooms are a treasure trove of bioactive compounds, but most of their immunomodulating activities have been attributed to polysaccharides (long-chain, simple sugars) and glycoproteins (polysaccharides naturally associated with proteins). These compounds activate a variety of immune responses.

Mushrooms for Immune Defense

  • Shiitake (Lentinula edodes): Lentinan, the beta glucan from shiitake, has been studied more extensively than similar substances and may be one of the most effective immunomodulators. Numerous studies have shown its ability to stimulate Natural Killer cell, T-cell, and macrophage-dependent responses.†

  • Reishi (Ganoderma lucidum): Reishi’s polysaccharides may stimulate macrophages and enhance T-cell proliferation, according to in vitro studies.†

  • Turkey Tails (Trametes versicolor): These mushrooms have a long history of traditional use in Asia. One in vitro study suggests that its polysaccharides stimulate macrophages.

  • Almond portabella (Agaricus blazei): This mushroom may stimulate the immune system by increasing T-cell activity, according to animal studies.

  • Cordyceps (Cordyceps sinensis): Cordyceps came to international attention during National Games in China when, in one week, three women’s track and field world records were broken. The coach partially credited a cordyceps elixir.  Cordyceps was found to augment antibody and other immune responses in one animal study, and a cordyceps polysaccharide was found to elevate cytokines in vitro.

  • Maitake (Grifola frondosa): Maitake enhances the activities of Natural Killer cells, T-cells and macrophages, according to animal studies. MUSHROOM IMMUNE DEFENSE contains MaitakeGold 404®, a highly specialized maitake product, rich in beta-glucans, which is the only maitake beta-glucan fraction endorsed by the world’s premier maitake researcher, Dr. Hiroaki Nanba, Ph.D.
Advanced Nutrition: Dr. Nanba's Maitake Beta-Factor™ (beta-glucan) Fraction

Beta-glucan is a complex sugar (polysaccharide) derived from the cell wall of baker’s yeast, oat and barley fiber, and many mushrooms. Beta-glucans bind to receptor sites on macrophages and neutrophils, which are part of the immune system’s first line of defense. This nutrient has been widely researched for its immune-supportive properties.

The Immune System

The immune system is a complex network of specialized tissues, organs, cells, and biochemicals.

Innate immunity is present at birth and provides the first line of defense. The skin, mucus secretions, and stomach acidity are examples of innate immunity. Adaptive immunity is acquired later in life, and includes elements such as antigens that generate antibodies, or white blood cells, T-cells, and B-cells. Amazingly, the adaptive immune system retains a memory of all its activities.

Mushroom Immune Defense contains 10 additional mushrooms. By carefully combining these mushrooms and fortifying them with extracts, Mushroom Immune Defense offers a broad-spectrum, high potency, complete mushroom product. Vitamin C is added to enhance absorption and activity.

Remember, a focus on immune support can pay tremendous dividends for your entire life. If you are dedicated to good health you want a powerful formula on your side, such as Mushroom Immune Defense.

Boost Your Immune System During the Winter Season


Kurashige S, et al. 1997. Immunopharmacol Immunotoxicol 1997 19(2):175-83.

Sherwood ER, Williams DL, McNamee RB, Jones EL, Browder IW, Di Luzio NR. Enhancement of interleukin-1 and interleukin-2 production by soluble glucan.  Int J Immunopharmacol (1987) 9(3): 261-267.

Wang S. Y. et al. 1994. Program and Abstracts of the ’94 International Symposium on Ganoderma Research. Beijing: Beijing Medical University.

Wasser S. P. and Weis A. L. 1999a. Crit Rev Immunol, 19, 65-96.

Supplement Facts - Mushroom Immune Defense

Tablets per Container: 60 Tablets
Serving Size: One (1) to Two (2) Tablets
Servings per Container: 30 to 60

Supplement Facts for 1,025 mg Capsule
Serving Size: 2 tablets
Amount per Serving % Daily Value
Calories 10  
Total Carbohydrates 2 g 1%
Vitamin C (as ascorbic acid) 100 mg 167%
Shiitake Mycelia Biomass 200 mg
Reishi Mycelia Biomass 200 mg
Maitake Mycelia Biomass 200 mg
Turkey Tail Mycelia Biomass 150 mg
Proprietary Blend: 1.3 g

Agaricus blazei Mycelia Biomass, Hericium erinaceous Mycelia Biomass, Flammulina velutipes Mycelia Biomass, Artist's Conk Mycelia Biomass, Tremella Mycelia Biomass, Schizophyllum commune Mycelia Biomass, Poria Mycelia Biomass, Grifola umbellata Mycelia Biomass, Pleurotus ostreatus Mycelia Biomass, Cordyceps sinensis Mycelia Biomass, Cordyceps militaris Mycelia Biomass, Armilleria mellea Mycelia Biomass, Maitake Mushroom Extract, Turkey Tail Mushroom Extract, Cordyceps sinensis CS-4 Standardized Extract (0.1% adenosine), Agaricus blazei Mushroom Extract, Shiitake Mushroom Extract, Reishi Mushroom Extract, and Dr. Namba's Maitake Beta-Factor™ (beta-glucan) Fraction††.

*Percent Daily Value (%DV) are based on a 2,000 calorie diet.

† Daily Value not established.

†† Consists of MaitakeGold 404® which is a registered trademark of the Tradeworks Group, Inc. U.S. Patent number 5,854,404.

Other Ingredients: Stearic acid, colloidal silicon dioxide, and modified cellulose gum. Contains gluten.

Suggested Use: 1 to 2 tablets a day in between meals.

Note: If you are pregnant, may become pregnant, or breastfeeding, consult your healthcare professional before using this product.

Do not use if either tamper-evident seal is broken or missing. Keep out of the reach of children.

Manufactured by Source Naturals.

† These statements have not been evaluated by the U.S. Food and Drug Administration (FDA) or This product is not intended to diagnose, treat, cure or prevent any disease. The information provided on this site is for informational purposes only and is not intended as a substitute for advice from your physician or other health care professional or any information contained on or in any product label or packaging. You should not use the information on this site for diagnosis or treatment of any health problem or for prescription of any medication or other treatment. You should consult with a health care professional before starting any diet, exercise or supplementation program, before taking any medication, or if you have or suspect you might have a health problem, or are pregnant. When you receive an item, carefully read all labels, warnings, and directions before use. Actual product packaging and materials may contain more and/or different information than shown on this website.

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